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The role of plasma membranes in hepatotoxic effects

  • Topic I: Drugs and Cellular Membranes
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References

  • Frimmer, M.: The influence of physical conditions on swelling and K+-release in perfused rat livers poisoned with phalloidin. Naunyn-Schmiedebergs Arch. Pharmacol. 275, 393–403 (1972)

    Google Scholar 

  • Frimmer, M., Gries, J., Hegner, D., Schnorr, B.: Untersuchungen zum Wirkungsmechanismus des Phalloidins. Freisetzung von lysosomalen Enzymen und von Kalium. Naunyn-Schmiedebergs Arch. Pharmacol. 258, 197–214 (1967)

    Google Scholar 

  • Frimmer, M., Homann, J., Petzinger, E., Rufeger, U., Scharmann, W.: Comparative studies on isolated rat hepatocytes and As-30D-hepatoma cells with leucocidin from pseudomonas aeruginosa. Naunyn-Schmiedebergs Arch. Pharmacol. in press (1976)

  • Frimmer, M., Kroker, R.: The role of extracellular K+-concentrations in phalloidin effects on isolated hepatocytes and perfused rat livers. Naunyn-Schmiedebergs Arch. Pharmacol. 278, 285–292 (1973)

    Google Scholar 

  • Frimmer, M., Kroker, R.: Phalloidin poisoning of isolated hepatocytes. Lack of enzyme release. Naunyn-Schmiedebergs Arch. Pharmacol. 279, 99–104 (1973)

    Google Scholar 

  • Frimmer, M., Kroker, R., Porstendörfer, J.: The mode of action of phalloidin: Demonstration of rapid deformation of isolated hepatocytes by scanning electron microscopy. Naunyn-Schmiedebergs Arch. Pharmacol. 284, 395–398 (1974)

    Google Scholar 

  • Frimmer, M., Scharmann, W.: Toxicity of a highly purified leucocidin from Pseudomonas aeruginosa in perfused rat livers. Naunyn-Schmiedebergs Arch. Pharmacol. 288, 123–132 (1975)

    Google Scholar 

  • Frimmer, M., Petzinger, E.: Phalloidin-Antagonisten. 3. Mitteilung. Arzneim. Forsch. 25, 1423–1426 (1975)

    Google Scholar 

  • Govindan, V.M., Faulstich, H., Wieland, Th., Agostini, B., Hasselbach, W.: In vitro effect of phalloidin on plasma membrane preparation from rat liver. Naturwissenschaften 59, 521–522 (1972)

    Google Scholar 

  • Hegner, D.: Investigations on the effect of phalloidin on isolated rat liver membranes. Naunyn-Schmiedebergs Arch. Pharmacol. 274, R 49 (1972)

    Google Scholar 

  • Hegner, D., Petter, A., Kroker, R., Anwer, M.S., Scharmann, W., Breuninger, V.: Leucocidin from Pseudomonas aeruginosa and membrane functions. Naunyn-Schmiedebergs Arch. Pharmacol. 293, 49–55 (1976)

    Google Scholar 

  • Kroker, R., Hegner, D.: Solubilization of phalloidin binding sites from rat liver hepatocytes and plasma membranes by trypsin. Naunyn-Schmiedebergs Arch. Pharmacol. 279, 339–346 (1973)

    Google Scholar 

  • Lengsfeld, A., Jahn, W.: Endocytose an der perfundierten Raftenleber nach Phalloidinvergiftung. Cytobiol. 9, 391–400 (1974)

    Google Scholar 

  • Lengsfeld, A.M., Löw, J., Wieland, Th., Dancker, P., Hasselbach, W.: Inferaction of phalloidin with actin. Proc. Nat. Acad. Sci. (USA) 71, 2803–2807 (1974)

    Google Scholar 

  • Lutz, F., Glossmann, H., Frimmer, M.: Binding of3H-desmethylphalloin to isolated plasma membranes from rat liver. Naunyn-Schmiedebergs Arch. Pharmacol. 273, 341–351 (1972)

    Google Scholar 

  • Petzinger, E., Seeger, R.: Scanning electron microscopical studies on the cytolytic effect of phallolysin on isolated hepatocytes and AS-30D hepatoma cells. Naunyn-Schmiedebergs Arch. Pharmacol. in press

  • Seeger, R.: Demonstration and isolation of phallolysin, a hemolytic toxin from Amanita phalloides. Naunyn-Schmiedebergs Arch. Pharmacol. 287, 277–287 (1975)

    Google Scholar 

  • Seeger, R., Burkhardt, M.: The hemolytic effect of phallolysin. Naunyn-Schmiedebergs Arch. Pharmacol. 293, 163–170 (1976)

    Google Scholar 

  • Seeger, R., Scharrer, H., Haupt, M.: Phallolysin, ein hochmolekulares Toxin aus Amanita phalloides. Experientia (Basel) 29, 829 (1973)

    Google Scholar 

  • Tosteson, D. C., Andreoli, T.E., Tiefenberg, M., Cook, P.: The effect of macrocyclic compounds on cation transport in sheep red cells and thin and thick lipid membranes. J. Gen. Physiol. 51, 373s-384s (1968)

    Google Scholar 

  • Tuchweber, B., Kovacs, K., Khandekar, J.D., Garg, B.D.: Peliosis-like changes induced by phalloidin in rat liver. J. Med. 4, 327–345 (1973)

    Google Scholar 

  • Weiss, E., Sterz, I., Frimmer, M., Kroker, R.: Electron microscopy of isolated rat hepatocytes before and after treatment with phalloidin. Beitr. Pathol. Anat. Allg. Pathol. 150, 345–356 (1973)

    Google Scholar 

  • Wieland, Th., Schäfer, A., Govindan, V.M., Faulstich, H.: Interaction of phalloidin with actin. In: Pathogenesis and mechanisms of liver cell necrosis Ed. D. Keppler 1975, MTP Press Ltd. Lancester.

    Google Scholar 

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Authors and Affiliations

  1. Institut für Pharmakologie und Toxikologie, Fachbereich Veterinärmedizin, Universität Giessen, D-6300, Giessen, Federal Republic of Germany

    M. Frimmer

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  1. M. Frimmer
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Frimmer, M. The role of plasma membranes in hepatotoxic effects. Naunyn-Schmiedeberg's Arch. Pharmacol. 297 (Suppl 1), S15–S19 (1977). https://doi.org/10.1007/BF00587764

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