Summary
Following acute hemorrhage in dogs the kinetics of platelet aggregation were studied with a formerly described photoelectrical method. This technique allows continuous and quantitative measurements of platelet aggregates in flowing blood. Comparative investigations in the femoral artery and in the right ventricle of the heart indicated the initiation of platelet aggregation in the venous blood at an earlier phase of hemorrhage. The aggregates formed intravenously are trapped in the microvasculature of the pulmonary system. This may contribute to the delay in appearing of aggregates in the arterial blood.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Benner, K. U., Frede, K. E., Lauterjung, K. L.: In vitro investigations with a new method for continuous and quantitative measurements of platelet aggregates in flowing blood. Pflügers Arch.320, 142–151 (1970).
Berman, H. J., Fulton, G. P.: The microcirculation as related to shock. In: Shock and Hypotension. Edit. by L. C. Mills and J. H. Moyer. New York-London: Grune and Stratton 1965.
Brecher, G., Cronkite, E. P.: Morphology and enumeration of human blood platelets. J. appl. Physiol.3, 365–377 (1950).
Brinkhous, K. M., Scarborough, D. E.: Some mechanisms of thrombus formation and hemorrhage following trauma. J. Trauma9, 684–691 (1969).
Dhall, D. P., McKenzie, F. N., Arfors, K.-E., Matheson, N. A.: Platelet behaviour in dogs during and after moderate and severe haemorrhage. Europ. surg. Res.1, 282–289 (1969).
Frede, K. E., Benner, K. U.: Quantitative measurements of platelet aggregation in vivo induced by adenosine diphosphate. Pflügers ARch.324, 319–327 (1971).
Hardaway, R. M., Johnson, D. G., Elovitz, M. J., Houchin, D. N., Jenkins, E. B., Burns, J. W., Jackson, D. R.: Influence of trauma and hemolysis on hemorrhagic shock in dogs. J. Trauma4, 624–641 (1964).
Hissen, W., Swank, R. L.: Screen filtration pressure and pulmonary hypertension. Amer. J. Physiol.209, 715–722 (1965).
Ljungqvist, U., Bergentz, S. E., Leandoer, L.: Platelet adhesiveness and aggregability after acute haemorrhage in the dog. Acta chir. scand.137, 1–6 (1971).
Michal, F., Firkin, B. G.: Physiological and pharmacological aspects of the platelet. Ann. Rev. Pharmacol.9, 95–118 (1969).
Robb, H. J.: The role of micro-embolism in the production of irreversible shock. Ann. Surg.158, 685–692 (1963).
Schneider, M.: Zur Pathophysiologie der verschiedenen Schockformen. Bibl. haemat. (Basel)16, 10–26 (1963).
Sinakos, Z., Caen, J. P.: Platelet aggregation in mammalians (human, rat, rabbit, guinea-pig, horse, dog). A Comparative Study. Thrombos. Diathes. haemorrh. (Stuttg.)17, 99–111 (1967).
Swank, R. L.: Adhesiveness of platelets and leukocytes during acute exsanguination. Amer. J. Physiol.202, 261–264 (1962).
—, Hissen, W., Fellman, J. H.: 5-hydroxytryptamine (Serotonin) in acute hypotensive shock. Amer. J. Physiol.207, 215–222 (1964).
Turpini, R., Stefanini, M.: The nature and mechanism of the hemostatic breakdown in the course of experimental hemorrhagic shock. J. clin. Invest.38, 53–65 (1959).
Walker, W. F., Zileli, M. S., Reutter, F. W., Shoemaker, W. C., Friend, D., Moore, F. D.: Adrenal medullary secretion in hemorrhagic shock. Amer. J. Physiol.197, 773–780 (1959).
Wiggers, C. J.: Physiology of shock. New York: The Commonwealth Fund 1950.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Benner, K.U., Frede, K.E. Continuous determination of platelet aggregation during acute hemorrhage in the arterial and venous system of dogs. Pflugers Arch. 328, 185–192 (1971). https://doi.org/10.1007/BF00587729
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00587729