Summary
We report the long-term metabolic observations made on 37 patients after simultaneous pancreas and kidney transplantation. Plasma C-peptide levels were above the physiological range in all patients and there was no significant difference between patients undergoing delayed duct occlusion (n=12) or those with drainage of exocrine secretion into the urinary bladder (n=25). HbA1c was equally at the upper end of the normal range in both subsets of patients. Mean fasting cholesterol (237 mg/dl) and triglycerides (122 mg/dl) were normal, and HDL-cholesterol was above normal with an average concentration of 77 mg/dl. Two patients underwent an oral fat tolerance test and showed extremely low postprandial lipaemia and very high lipoprotein lipase activities. We conclude that patients with a functioning pancreas graft persistently demonstrate normoglycaemia, elevated C-peptide, and a very favourable lipid profile both in the fasting and the postprandial state.
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Drexel, H., Palos, G., Königsrainer, A. et al. Long-term follow-up of glycaemic control and parameters of lipid transport after pancreas transplantation. Diabetologia 34 (Suppl 1), S47–S50 (1991). https://doi.org/10.1007/BF00587618
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DOI: https://doi.org/10.1007/BF00587618