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Substance P: A Powerful intestinal vasodilator in the pig

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Abstract

In anaesthetized young pigs the influence of intra-arterial infusions of Substance P (SP) on mesenteric vascular resistance is studied, both before and after serotoninergic and nervous conductivity blockade by dihydroergotamine (DHE) and tetrodotoxin (TTX). SP has a strong dilator effect on pig mesenterial vessels, which is not significantly modified by DHE or TTX; presumably SP acts directly on the vascular smooth muscle. By comparing the threshold level of SP with that of other intestinal vasodilators, it may be concluded that SP is the most powerful intestinal vasodilator so far experimented in the pig.

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Authors and Affiliations

  1. Laboratory of Veterinary Physiology, University of Antwerp, State University Centre, Slachthuislaan 68, B-2000, Antwerp, Belgium

    E. Schrauwen & A. Houvenaghel

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  1. E. Schrauwen
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  2. A. Houvenaghel
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Schrauwen, E., Houvenaghel, A. Substance P: A Powerful intestinal vasodilator in the pig. Pflugers Arch. 386, 281–284 (1980). https://doi.org/10.1007/BF00587480

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  • DOI: https://doi.org/10.1007/BF00587480

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