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Cortically induced inhibition in the dorsal column nuclei of monkeys

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Summary

Corticofugal inhibition of somatosensory transmission in the cuneate nucleus of monkeys under chloralose was investigated with particular reference to the time course of primary afferent depolarization (PAD), the cortical origin of its pathway, and its sensitivity to small additional doses of Nembutal. Corticofugal effects were also compared with PAD elicited by conditioning peripheral nerve stimuli. It is concluded that the pathway mediating corticofugal inhibition has its origin in areas in front of the Rolandic fissure. It is suggested that the pathway is indirect and involves the bulbar reticular formation.

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References

  • Harris, F., Jabbur, S. J., Morse, R. W., Towe, A. L.: Influence of the cerebral cortex on the cuneate nucleus of the monkey. Nature (Lond.)208, 1215–1216 (1965).

    Google Scholar 

  • Hepp-Reymond, M.-C., Wiesendanger, M.: Pyramidal influence on the spinal trigeminal nucleus of the cat. Arch. ital. Biol.107, 54–66 (1969).

    Google Scholar 

  • Jabbur, S. J., Towe, A. L.: Cortical excitation of neurons in dorsal column nuclei of cat, including an analysis of pathways. J. Neurophysiol.24, 499–509 (1961).

    Google Scholar 

  • Kuypers, H. G. J. M.: Central cortical projections to motor and somatosensory cell groups. Brain83, 161–188 (1960).

    Google Scholar 

  • Wall, P. D.: Excitability change in afferent fibre terminations and their relation to slow potentials. J. Physiol. (Lond.)142, 1–21 (1958).

    Google Scholar 

  • Wiesendanger, M.: The pyramidal tract. Recent investigations on its morphology and function. Ergebn. Physiol.61, 72–136 (1969).

    Google Scholar 

  • —, Felix, D.: Pyramidal excitation of lemniscal neurons and facilitation of sensory transmission in the spinal trigeminal nucleus of the cat. Exp. Neurol.25, 1–17 (1969).

    Google Scholar 

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Authors and Affiliations

  1. Institute for Brain Research, University of Zürich, August Forel-Str. 1, CH-8008, Zürich, Switzerland

    Dominik Felix & Mario Wiesendanger

Authors
  1. Dominik Felix
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  2. Mario Wiesendanger
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Additional information

This work was supported by a grant from the Swiss National Foundation for Scientific Research (No. 4447).

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Felix, D., Wiesendanger, M. Cortically induced inhibition in the dorsal column nuclei of monkeys. Pflugers Arch. 320, 285–288 (1970). https://doi.org/10.1007/BF00587459

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  • DOI: https://doi.org/10.1007/BF00587459

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