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Afferente Verbindungen zu schnell- und langsamleitenden Pyramidenbahnneuronen der Katze

Afferent connections to fast and slow conducting pyramidal tract neurons

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Summary

Pyramidal tract neurons of cats under chloralose anesthesia have been classified with respect ot their axonal conduction velocity in two groups of fast and slow conducting neurons. Afferent connections of both groups have been analyzed. A significantly higher response rate of fast PT units has been established after electric stimulation of cutaneous nerves of both forepaws, stimulation of the thalamic ventrolateral nucleus as well as after photic stimulation of the contralateral eye. Depending on the site of stimulation, 74–93% of the fast PT units could be excited, but under the same conditions only 28–53% of the slow PT units showed spike responses. The latencies of the responses were equal for both cell types with stimulation of ipsilateral forepaw or the eye. However when a stimulus was applied at the ventrolateral nucleus, fast PT units only showed a response after a latency of less than 5 msec. When the contralateral forepaw was stimulated, 60% of the fast PT units, but none of the slow ones responded within the first 22 msec after stimulation. The conclusion has been made that crossed oligosynaptic connections from cutaneous afferents may project exclusively to the fast PT units.

Zusammenfassung

Pyramidenbahnneurone chloralosenarkotisierter Katzen wurden nach der Leitungsgeschwindigkeit ihrer Axone in schnelleitende (sPTN) und langsamleitende (IPTN) eingeteilt und afferente Verbindungen beider Zellpopulationen untersucht. Bei elektrischer Reizung der Hautnerven beider Vorderpfoten, sowie im Nucleus ventrolateralis des Thalamus und auch bei photischer Reizung des kontralateralen Auges fand sich eine signifikant größere Ansprechbarkeit der sPTN. Je nach Reizstelle reagierten 74–93% der sPTN, aber nur 28–53% der IPTN mit Spikeentladungen. Die Latenzzeiten dieser Entladungen waren nach Reizung der ipsilateralen Vorderpfote und nach photischen Reizen bei beiden Zellpopulationen etwa gleich. Hingegen reagierten bei Reizung des Nucleus ventrolateralis nur die sPTN innerhalb der ersten 5 msec. Bei Reizung des Hautnerven der kontralateralen Vorderpfote zeigten 60% der sPTN, aber keine IPTN eine Entladung innerhalb der ersten 22 msec nach dem Reiz. Die Resultate legen die Annahme einer gekreuzten oligosynaptischen Verbindung von Hautafferenzen zu den sPTN nahe.

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Authors and Affiliations

  1. Institut für Hirnforschung der Universität Zürich, August Forel-Str. 1, CH-8008, Zürich, (Schweiz)

    Albert Wettstein & Hermann O. Handwerker

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  1. Albert Wettstein
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  2. Hermann O. Handwerker
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Mit Unterstützung der Kredite 4447 und 4356 des Schweizerischen Nationalfonds für die wissenschaftliche Forschung.

Für bereitwillige Mitarbeit danken wir herzlich: Elektronik: P. Stoller; Operation: A. Fäh; Foto: L. Decoppet; Histologie: I. Gyarmati; Elektroden und Grafiken: S. Bollinger. Herrn Prof. Dr. K. Akert, Herrn Prof. Dr. G. Baumgartner und Herrn PD Dr. M. Wiesendanger danken wir für wohlwollende Beratung und Kritik.

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Wettstein, A., Handwerker, H.O. Afferente Verbindungen zu schnell- und langsamleitenden Pyramidenbahnneuronen der Katze. Pflugers Arch. 320, 247–260 (1970). https://doi.org/10.1007/BF00587456

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  • DOI: https://doi.org/10.1007/BF00587456

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