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Untersuchungen zum zentralen chemosensiblen Mechanismus der Atmung

IV. Beobachtungen an anaesthesierten und dezerebrierten Katzen

Studies on the central chemosensitive mechanism of respiration

IV. Observations in anesthetized and in decerebrate cats

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Summary

The ventilatory response to changes in the extracellular pH in the medullary tissue (pH e ) was studied in decerebrate cats and in cats anesthetized with chloralose-urethane. pH e was varied by changing theP ACO2 and by perfusion of the ventral medullary surface with solutions of different bicarbonate concentrations. For comparison,P ACO2 response curves of respiration were recorded in the decerebrate animals without simultaneous perfusion.

  1. 1.

    TheP ACO2 response curves ofV T obtained during perfusion of the ventral medullary surface with mock CSF show a smaller slope than the control curves recorded without perfusion.

  2. 2.

    The frequency response to changes inP ACO2 resembles the response obtained under control conditions only during alkaline perfusion (pH 7.6–7.8). More acid perfusates cause a decrease of frequency, which is probably due to their effect on calcium ionization.

  3. 3.

    During perfusion, ventilation does not reach the maximal values observed under control conditions. This is mainly caused by the diminished frequency response.

  4. 4.

    A similar behaviour ofV T ,f andV is observed in anethetized cats. However,f andV, less obviouslyV T , are distinctly diminished as compared with the decerebrate animals.

  5. 5.

    The pH e -response ofV T is not diminished during anesthesia, which is attributed to a local wash-out ot the narcotics by the perfusion. Frequency response and ventilatory response, however, are reduced as compared with decrerebrate cats.

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Authors and Affiliations

  1. Institut für Physiologie der Ruhr-Universität, Bochum

    J. Berndt, W. Berger, K. Berger & M. Schmidt

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  1. J. Berndt
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  2. W. Berger
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  3. K. Berger
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  4. M. Schmidt
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Berndt, J., Berger, W., Berger, K. et al. Untersuchungen zum zentralen chemosensiblen Mechanismus der Atmung. Pflugers Arch. 332, 184–197 (1972). https://doi.org/10.1007/BF00587446

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  • DOI: https://doi.org/10.1007/BF00587446

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