Effect of barbiturates on GFR and fluid reabsorption along proximal convoluted tubules and loops of henle in rats
- 19 Downloads
In the present study we investigated the possibility that GFR and fluid reabsorption are systematically altered by dose and/or structure of different barbiturate compounds. The results show that filtration and absorption rates are identical in rats anaesthetized with 100 or 150 mg/kg BW. Elevating the administered amount by intravenous injections of inactin did not alter renal functions compared to values measured immediately before the additional administration. No differences of GFR and absorption rates were noted when the effect of inactin, amytal, and nembutal in doses necessary to induce and maintain anaesthesia was compared. Absolute and fractional absorption was observed to decrease by 20 to 25% in the first 3 h after induction of anaesthesia independent of the anaesthetic used. Our results suggest that filtration and absorption rates are not systematically modified by specific anaesthetic effects, at least not when doses are kept close to the necessary minimum.
Key wordsMicropuncture Barbiturates Nephron Filtration Rate Fluid Reabsorption
Unable to display preview. Download preview PDF.
- 1.Davis, J. M., Schnermann, J., Horster, M.: Micropuncture method for the determination of nephron filtration rate. A recollection study. Pflügers Arch.333, 271 (1972)Google Scholar
- 2.Elmer, M., Eskildsen, P. C., Kristensen, L. Ø. Leyssac, P. P.: A comparison of renal function in rats anesthetized with inactin and sodium amytal. Acta physiol. scand.86, 41 (1972)Google Scholar
- 3.Führ, J., Kaczmarczyk, J., Krüttgen, C. D.: Eine einfache Methode zur Inulinbestimmung für Nieren-Clearence-Untersuchungen bei Stoffwechselgesunden und Diabetikern. Klin. Wschr.33, 729 (1955)Google Scholar
- 4.Hilger, H. H., Klümper, J. D., Ullrich, K. J.: Wasserrückresorption und Ionentransport durch die Sammelrohrzellen der Säugetierniere. Pflügers Arch. ges. Physiol.267, 218 (1958)Google Scholar
- 5.Horster, M., Thurau, K.: Micropuncture studies on the filtration rate of single superficial and juxtamedullary glomeruli in the rat kidney. Pflügers Arch. ges. Physiol.301, 162 (1968)Google Scholar
- 6.Leyssac, P. P.: Dependence of glomerular filtration rate on proximal tubular reabsorption of salt. Acta physiol. scand.58, 236 (1963)Google Scholar
- 7.Schneider, W., Greger, R.: An improved microcuvette for photometric measurements. Pflügers Arch.311, 268 (1969)Google Scholar
- 8.Schnermann, J., Davis, J. M., Wunderlich, P., Levine, D. Z., Horster, M.: Technical problems in the micropuncture determination of nephron filtration rate and their functional implications. Pflügers Arch.329, 307 (1971)Google Scholar