Pflügers Archiv

, Volume 348, Issue 3, pp 197–204 | Cite as

Disturbances of the control of renin secretion in chronic one-kidney-goldblatt hypertension in the rat

  • Udo Helmchen
  • Ursula Kneissler
  • Georges Peters


Systolic blood pressure (BP) and plasma renin level (p.r.l.) were measured 1. in rats with chronic one-kidney-Goldblatt hypertension before, 1 1/2 h, 6 or 24 h after unclamping or sham-operation. 2. 6 h after 50 mg/kg furosemide i.p., and again 2 h after a subsequent nephrectomy.

P.r.l. in the chronic stage of one-kidney-Goldblatt hypertension did not differ from that in normal control animals. Sham-unclamping did not influence BP and did not cause a significant increase of p.r.l.

1 1/2 h after unclamping BP fell considerably to still hypertensive levels while p.r.l. fell to less than half its normal value. 6 to 24 h after unclamping, BP continued to fall, while p.r.l. progressively rose to reach 78% of its normal value. Furosemide diuresis caused an increase of p.r.l., but no fall of BP. 2 h after subsequent nephrectomy p.r.l. fell to undetectable levels and BP to its normal value.

The data suggest that the normal p.r.l. in the chronic stage of Goldblatt hypertension may be considered as inappropriate elevated in relation to blood pressure and sodium balance state due to partial protection of the kidney against regulatory influences by the presence of a clamp on the renal artery.

Key words

Renal Artery Constriction Experimental Renal Hypertension “Inapropriate” Renin Secretion Unclamping Furosemide Nephrectomy 


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Udo Helmchen
    • 1
    • 2
  • Ursula Kneissler
    • 1
    • 2
  • Georges Peters
    • 1
    • 2
  1. 1.Pathologisches Institut der Universität TübingenTübingenGermany
  2. 2.Institut de Pharmacologie de l'Université de LausanneSwitzerland

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