Skip to main content
SpringerLink
Log in

Effects of hypercalcemia on water and sodium excretion by the isolated dog kidney

  • Published:
Pflügers Archiv Aims and scope Submit manuscript

Summary

The effects of acute hypercalcemia on hemodynamics and on water and sodium excretion were studied on the blood-perfused isolated dog kidney. This model advantageously eliminates various factors which modify medullary osmolality and intrarenal hemodynamics, as well as collecting duct permeability. Calcium ion directly inhibits sodium reabsorption in the proximal tubule and in the ascending limb of Henle's loop, leading to increased sodium excretion rate and to decreased free water generation. The vasoconstrictive action of calcium, leading to decreased glomerular filtration rate, may mitigate the strong natriuretic effect of this ion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Antoniou, L. D., Eisner, G. M., Slotkoff, L. M., Lilienfield, L. S.: Relationship between sodium and calcium transport in the kidney. J. Lab. clin. Med.74, 410–420 (1969)

    Google Scholar 

  2. Argy, W. P., Handler, J. S., Orloff, J.: Ca2+ and Mg2+ effects on toad bladder response to cyclic AMP, theophylline and ADH analogues. Amer. J. Physiol.213, 803–808 (1967)

    Google Scholar 

  3. Bank, N., Aynedjian, H. S.: On the mechanism of hyposthenuria in hypercalcemia. J. clin. Invest.44, 681–693 (1965)

    Google Scholar 

  4. Beck, D., Levitin, H., Epstein, F. H.: Effect of intravenous infusion of calcium on renal concentrating ability. Amer. J. Physiol.197, 1118–1120 (1959)

    Google Scholar 

  5. Bennett, C. M.: Urine concentration and dilution in hypokalemic and hypercalcemic dogs. J. clin. Invest.49, 1447–1465 (1970)

    Google Scholar 

  6. Berkowitz, H. D., Miller, L. D., Itskowitz, H. D., Bovee, K. C.: Renal function in the isolated perfused kidney. Surg. Gynec. Obstet.127, 1257–1266 (1968)

    Google Scholar 

  7. Berliner, R. W., Bennett, C. M.: Concentration of urine in the mammalian kidney. Amer. J. Med.42, 777–789 (1967)

    Google Scholar 

  8. Brunnette, M., Aras, M.: A microinjection study of nephron permeability to calcium and magnesium. Amer. J. Physiol.221, 1442–1448 (1971)

    Google Scholar 

  9. Brunette, M. G., Vary, J., Carriere, S.: Hyposthenuria in hypercalcemia. Pflügers Arch.350, 9–23 (1974)

    Google Scholar 

  10. Chen, P. S., Neuman, W. F.: Renal excretion of Ca by the dog. Amer. J. Physiol.180, 623–631 (1955)

    Google Scholar 

  11. Curran, P. F., Herresa, F. C., Flanigan, W. J.: The effect of Ca and antidiuretic hormone on Na transport across frog skin. J. gen. Physiol.46, 1011–1027 (1963)

    Google Scholar 

  12. Davis, J. M., Schnermann, J.: The effect of antidiuretic hormone on the distribution of nephron filtration rates in rats with hereditary diabetes insipidus. Pflügers Arch.330, 323–334 (1971)

    Google Scholar 

  13. Di Bona, G. F.: Effect of hypercalcemia on renal tubular sodium handling in the rat. Amer. J. Physiol.220, 49–53 (1971)

    Google Scholar 

  14. Edwards, B. R., Sutton, R. A., Dirks, J. H.: Effect of calcium infusion on renal tubular reabsorption in the dog. Amer. J. Physiol.227, 13–18 (1974)

    Google Scholar 

  15. Epstein, F. H.: Calcium and the kidney. Amer. J. Med.45, 700–714 (1968)

    Google Scholar 

  16. Epstein, F. H., Beck, D., Carone, F. A., Levitin, H., Manitus, A.: Changes in renal concentrating ability produced by parathyroid extract. J. clin. Invest.38, 1214–1221 (1959)

    Google Scholar 

  17. Fisher, R. A., Yates, F.: Statistical tables for biological, agricultural and medical research. 3rd Edit. Edinburgh: Oliver and Boyd Ltd. 1948)

    Google Scholar 

  18. Frohlich, E. D., Scott, J. B., Haddy, F. J.: Effect of cations on resistance and responsiveness of renal and forelimb vascular beds. Amer. J. Physiol.203, 583–587 (1962)

    Google Scholar 

  19. Guignard, J. P., Barraclough, M. A., Jones, N. F.: Effect d'une perfusion intraveineuse de calcium sur le mécanisme de concentration urinaire. Helv. physiol. pharmacol. Acta26, 348–350 (1968)

    Google Scholar 

  20. Guignard, J. P., Jones, N. F., Barraclough, M. A.: Effect of brief hypercalcaemia on free water reabsorption during solute diuresis: Evidence for impairment of sodium transport in Henle's loop. Clin. Sci.39, 337–347 (1970)

    Google Scholar 

  21. Itskovitz, H. D., Stemper, J., Pacholczyk, D., McGiff, J. C.: Renal prostaglandins: Determinants of intrarenal distribution of blood flow. Clin. Sci. Mol. Med.45, (suppl. I), 321–324 (1973)

    Google Scholar 

  22. Jamison, R. L.: Recent advances in the physiology of Henle's loop and the collecting tubule system. Circulat. Res. Suppl.24–25, 1.91–1.100 (1974)

    Google Scholar 

  23. Lassiter, W. E., Frick, A., Rumrich, G., Ullrich, K. J.: Influence of ionic calcium on the water permeability of proximal and distal tubules in the rat kidney. Pflügers Arch. ges. Physiol.285, 90–95 (1965)

    Google Scholar 

  24. Leme, C. E., Wajchenberg, B. L.: Effects of acute intravenous infusion of calcium chloride on the renal concentrating and diluting mechanisms in man. Metabolism21, 1093–1103 (1972)

    Google Scholar 

  25. Lonigro, A. J., Itskovitz, H. D., Crowshaw, K., McGiff, J. C.: Dependency of RBF on prostaglandin synthesis in the dog Circulat. Res.32, 712–717 (1973)

    Google Scholar 

  26. Manitius, A., Levitin, H., Beck, D., Epstein, F. H.: On the mechanism of impairment of renal concentrating ability in hypercalcemia. J. clin. Invest.39, 693–696 (1960)

    Google Scholar 

  27. Massry, S. G., Coburn, J. W., Chapman, L. W., Kleeman, C. R.: Role of serum Ca, parathyroid hormone, and NaCl infusion on renal Ca and Na clearances. Amer. J. Physiol.214, 1403–1409 (1968)

    Google Scholar 

  28. Mueller, C. B., Surtshin, A., Carlin, M. R., White, H. L.: Glomerular and tubular influences on sodium and water excretion. Amer. J. Physiol.165, 411–422 (1951)

    Google Scholar 

  29. Nizet, A.: The isolated perfused kidney. Kidney Int.7, 1–11 (1975)

    Google Scholar 

  30. Nizet, A.: Physiologie du rein en survie extracorporelle. J. Urol. Néphrol.77, 909–927 (1971)

    Google Scholar 

  31. Nizet, A., Cuypers, Y., Deetjen, P., Kramer, K.: Functional capacity of the isolated perfused dog kidney. Pflügers Arch. ges. Physiol.296, 179–195 (1967)

    Google Scholar 

  32. Rector, F. C., Brunner, F. P., Seldin, D. W.: Mechanism of glomerulotubular balance. J. clin. Invest.45, 590–611 (1966)

    Google Scholar 

  33. Rosenbaum, B., Kinney, M. J., Scudder, F. C., Discala, V. A., Stein, R. M.: Effects of potassium depletion on renal tubular sodium and water reabsorption in the dog. Amer. J. Physiol.222, 928–937 (1972)

    Google Scholar 

  34. Seldin, D. W., Eknoyan, G., Suki, W. N., Rector, F. C.: Localization of diuretic action from pattern of water and electrolytes excretion. Ann. N. Y. Acad. Sci.139, 328–343 (1966)

    Google Scholar 

  35. Suki, W. N., Eknoyan, G., Rector, F. C., Seldin, D. W.: The renal diluting and concentrating mechanism in hypercalcemia. Nephron6, 50–61 (1969)

    Google Scholar 

  36. Vanherweghem, J.-L., Ducobu, J., d'Hollander, A.: Effects of indomethacin on renal hemodynamics and on water and sodium excretion by the isolated dog kidney. Pflügers Arch.357, 243–252 (1975)

    Google Scholar 

  37. Vanherweghem, J.-L., Ducobu, J., d'Hollander, A., Toussaint, C.: Interactions between furosemide and vasopressin on hemodynamics and on water excretion by the isolated dog kidney. Pflügers Arch. (in press, 1976)

  38. Wallach, S., Carter, A. C.: Metabolic and renal effects of acute hypercalcemia in dogs. Amer. J. Physiol.200, 359–366 (1961)

    Google Scholar 

  39. Waugh, A. H., Kubo, T.: Development of an isolated perfused dog kidney with improved function. Amer. J. Physiol.217, 277–290 (1969)

    Google Scholar 

  40. Yoffee, H. F., Dingman, J. F.: Effect of hypercalcemia on antidiuretic action of vasopressin. Metabolism9, 995–1004 (1960)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratorie de Médicine Expérimentale, Université Libre de Bruxelles and Fondation Médicale Reine Elisabeth, B-1020, Brussels, Belgium

    J. -L. Vanherweghem, J. Ducobu, A. D'Hollander & C. Toussaint

Authors
  1. J. -L. Vanherweghem
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Ducobu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. D'Hollander
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Toussaint
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vanherweghem, J.L., Ducobu, J., D'Hollander, A. et al. Effects of hypercalcemia on water and sodium excretion by the isolated dog kidney. Pflugers Arch. 363, 75–80 (1976). https://doi.org/10.1007/BF00587405

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00587405

Key words

Search

Navigation