Pflügers Archiv

, Volume 361, Issue 1, pp 79–81 | Cite as

Effects of cyanide and doxapram during panting

  • A. V. Ruiz


The ventilatory responses, blood gases and acid-base status to intravenous injections of KCN and doxapram hydrochloride were studied in anesthetized dogs during normothermia and thermally induced panting. In the normothermic animal, KCN evoked elevation of\(\dot V\) E (154.7%),V T (70.1%),f (48.3%),PaO2 (12.1%) and pH (0.098 units), whilePaCO2 diminished by 9.7 mm Hg. During panting, KCN infusions resulted in increases of\(\dot V\) E (24.5%),V T (46.6%),PaO2 (3.9%) and pH (0.034 units), whilef decreased (10.1%). Bolus injections of doxapram during normothermia increased\(\dot V\) E (32.6%),V T (18.8%) andf (17.1%). During panting\(\dot V\) E ,V T andf increased by 18.0%, 18.2% and 1.5%, respectively. These results demonstrate that the peripheral (arterial) chemoreceptors preserve the capacity to react to acute chemical stimuli in animals in which the thermal stimuli override the normal chemical control of respiration in order to control body temperature, and that this reaction contributes to the integrated respiratory drive.

Key words

Cyanide Doxapram Panting Control of respiration Thermoregulation Peripheral chemoreceptors 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Albers, C.: Der Mechanismus des Wärmehechelns beim Hund. I. Die Ventilation und die arteriellen Blutgase während des Wärmehechelns. Pflügers Arch. ges. Physiol.274, 125–147 (1961)Google Scholar
  2. Bouverot, P., Flandrois, R., Pucinelli, R., Dejours, P.: Étude du role des chémorécepteurs artériels dans la régulation de la respiration pulmonaire chez le chien éveillé. Arch. int. Pharmacodyn.157, 253–271 (1965)Google Scholar
  3. Byck, R.: The effect of hexametonium on the carotid chemoreceptor response to nicotine and cyanide. Brit. J. Pharmacol.16, 15–22 (1961)Google Scholar
  4. Edelman, N. H., Epstein, P. E., Lahiri, S., Cherniack, N. S.: Ventilatory responses to transient hypoxia and hypercapnia in man. Respir. Physiol17, 302–314 (1973)Google Scholar
  5. Funderburk, W. H., Alphin, R. S.: Electrical changes in the CNS produced by a new respiratory stimulant, AHR-619. Fed. Proc.21, 324 (1962)Google Scholar
  6. Hales, J. R., Bligh, J.: Respiratory responses of conscious dogs to severe heat stress. Experientia (Basel)47, 818–819 (1969)Google Scholar
  7. Hirsh, K., Wang, S. C.: Mechanism of specific respiratory stimulant action of doxapram. Fed. Proc.31, 372 (1972)Google Scholar
  8. Jacobs, L., Sampson, S. H., Comroe, J. H.: Carotid sinus versus carotid body origin of nicotine and cyanide bradycardia in the dog. Amer. J. Physiol.220, 472–476 (1971)Google Scholar
  9. Kappey, F., Albers, C., Schmidt, R.: Die ventilatorische CO2-Reaktion des Hundes während der Wärmetachypnoe. Pflügers Arch. ges. Physiol.275, 312–326 (1962)Google Scholar
  10. Kato, H., Buckley, J. P.: Possible sites of action of the respiratory stimulant effects of doxapram hydrochloride. J. Pharmacol. exp. Ther.144, 260–264 (1964)Google Scholar
  11. Krasney, J. A.: Cardiovascular responses to cyanide in awake sinoaortic denervated dogs. Amer. J. Physiol.220, 1361–1366 (1971)Google Scholar
  12. Mitchell, R. A., Bainton, C. R., Edelist, G.: Posthyperventilation apnea in awake dogs during metabolic acidosis and hypoxia. J. appl. Physiol.21, 1363–1367 (1966)Google Scholar
  13. Polak, A., Plum, F.: Comparison of new analeptics in barbiture poisoned animals. J. Pharmacol. exp. Ther.145, 27–33 (1964)Google Scholar
  14. Ruiz, A. V.: Ventilatory response of the panting dog to hypoxia. Pflügers Arch.340, 89–99 (1973)Google Scholar
  15. Ruiz, A. V.: Effects of cyanide and doxapram during hypothermia. Pflügers Arch.361, 75–78 (1975)Google Scholar
  16. Severinghaus, J. W.: Blood gas calculator. J. appl. Physiol.21, 1108–1116 (1966)Google Scholar
  17. Steel, R. C., Torrie, J. H.: Principles and procedures of statistics. New York: McGraw-Hill Book Co., Inc. 1960Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • A. V. Ruiz
    • 1
  1. 1.Departments of Physiology and Basic Sciences of the Medical and Veterinary SchoolsUniversity of AntioquiaMedellinColombia, South America

Personalised recommendations