Pflügers Archiv

, Volume 361, Issue 1, pp 79–81 | Cite as

Effects of cyanide and doxapram during panting

  • A. V. Ruiz
Article

Summary

The ventilatory responses, blood gases and acid-base status to intravenous injections of KCN and doxapram hydrochloride were studied in anesthetized dogs during normothermia and thermally induced panting. In the normothermic animal, KCN evoked elevation of\(\dot V\) E (154.7%),V T (70.1%),f (48.3%),PaO2 (12.1%) and pH (0.098 units), whilePaCO2 diminished by 9.7 mm Hg. During panting, KCN infusions resulted in increases of\(\dot V\) E (24.5%),V T (46.6%),PaO2 (3.9%) and pH (0.034 units), whilef decreased (10.1%). Bolus injections of doxapram during normothermia increased\(\dot V\) E (32.6%),V T (18.8%) andf (17.1%). During panting\(\dot V\) E ,V T andf increased by 18.0%, 18.2% and 1.5%, respectively. These results demonstrate that the peripheral (arterial) chemoreceptors preserve the capacity to react to acute chemical stimuli in animals in which the thermal stimuli override the normal chemical control of respiration in order to control body temperature, and that this reaction contributes to the integrated respiratory drive.

Key words

Cyanide Doxapram Panting Control of respiration Thermoregulation Peripheral chemoreceptors 

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • A. V. Ruiz
    • 1
  1. 1.Departments of Physiology and Basic Sciences of the Medical and Veterinary SchoolsUniversity of AntioquiaMedellinColombia, South America

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