Pflügers Archiv

, Volume 361, Issue 1, pp 65–68 | Cite as

Platelet adhesiveness and cancer cell stickiness

A comparative study
  • E. Jacobi


Comparing platelet adhesiveness and cancer cell stickiness under the conditions of the so-called Fibre test showed that:
  1. 1.

    Platelets aggregate in the first few seconds only, whereas Yoshida sarcoma cells accumulate continuously.

  2. 2.

    Platelets show a characteristic velocity profile. Platelet adhesiveness shows a maximum at a velocity of 7 cm/sec. Yoshida sarcoma cells adhere better at low flow velocity.

  3. 3.

    An experimentally induced electric current (streaming electric current) of ca. 40 mV augments platelet adhesiveness to twice the basal value, whereas Yoshida sarcoma cells remain uninfluenced by the current.


These results suggest an interaction between platelets and vessel wall, whereas Yoshida sarcoma cells adhere passively.

Key words

Fibre test Platelet adhesiveness Cancer cell stickiness Interaction with surface 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Eberth, J. E., Schimmelbusch, C.: Experimentelle Untersuchungen über Thrombose. Virchows Arch. path. Anat.103, H. 1,105, H. 2 (1885)Google Scholar
  2. 2.
    Gastpar, H.: Stickness of platelets and tumor cell influenced by drugs. In: Platelet adhesion, E.F. Mammen et al., pp. 291–303. Stuttgart: Schattauer 1970Google Scholar
  3. 3.
    Hagemann, G., Jacobi, E., Joost, P., Poliwoda, H.: Sind physikalische Vorgänge an der Thrombogenese beteiligt? Studia biophysica (Berl.)26, 221–232 (1971)Google Scholar
  4. 4.
    Hildegard, P.: The role of blood platelets in experimental metastases. Brit. J. Cancer28, 429–435 (1973)Google Scholar
  5. 5.
    Jacobi, E., Hagemann, G., Poliwoda, H.: Einein-vitro-Methode zur Bestimmung der Thromozytenadhäsivität. Thrombos. Diathes. haemorrh. (Stuttg.)26, 192–202 (1971)Google Scholar
  6. 6.
    Poliwoda, H.: personal Communication. Thrombos. Diathes. haemorrh. (Stuttg.) (in press, 1976)Google Scholar
  7. 7.
    Poliwoda, H., Hagemann, G., Jacobi, E.: Geschwindigkeits-abhängige Wechselwirkungen zwischen. Thrombozyten und verschiedenen Oberflächen. Klin. Wschr.48, 442–443 (1970)Google Scholar
  8. 8.
    Wood, S., Jr., Hilgard, P.: Arvin-induced hypofibrinogenemia and metastasis formation from blood-borne cancer cells. Johns Hopk. med. J.133, 207–213 (1973)Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • E. Jacobi
    • 1
  1. 1.II. Medizinische und Poliklinik der UniversitätDüsseldorf 1Germany

Personalised recommendations