The role of the spleen in determination of red cell volume with Cr51-labelled erythrocytes in the intact dog
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The uptake of Cr51-tagged red cells by the canine spleen was demonstrated by external counting with a collimated scintillation detector and simultaneous measurements of activity in blood. After injection of tracer it appeared necessary to draw several blood samples over a period up to 60 min and to perform an exponential extrapolation of activity to time zero in order to obtain correct values of circulating red cell volume in dogs with intact spleen. After complete mixing, the disappearance rate of Cr51 from the circulating blood closely corresponds to the volume of red cells trapped within the spleen.
Key wordsDisappearance Rate of Tracer Splenic Uptake of Tagged Cells
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