Pflügers Archiv

, Volume 341, Issue 2, pp 113–120 | Cite as

Effect on blood pressure of intravenous administration of a phospholipid renin preinhibitor and its active form in renal hypertensive rats

  • A. Antonello
  • B. Baggio
  • S. Favaro
  • A. Corsini
  • S. Todesco
  • A. Borsatti
Article

Summary

It has been evaluated the effect of acute intravenous administration of a phospholipid renin preinhibitor and its active form (lysophospholipid) in rats rendered hypertensive by unilateral renal ischemia, by continuous infusion of homologous renin and in normal control rats.

Both the substances have no effect on blood pressure in normal rats.

In rats rendered hypertensive by unilateral renal ischemia or by continuous infusion of homologous renin, injection of inactive phospholipid does not lower blood pressure, while the same quantity of active lysophospholipid brings about a significant reduction. This observation suggest either the absence of circulating specific phospholipase(s), or their non activation of the preinhibitor.

Key words

Phospholipid Renin Preinhibitor Lysophospholipid Renin Inhibitor Renal Hypertensive Rats Effect on Blood Pressure 

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References

  1. 1.
    Boucher, R., Veyrat, R., de Champlain, J., Genest, J.: New procedure for measurement of human angiotensin and renin activity levels. Canad. med. Ass. J.90, 194 (1964).Google Scholar
  2. 2.
    Bumpus, F. M.: Factors affecting the formation and destruction of angiotensin. In: L'hypertension arterielle, ed. by P. Milliez and P. Tcherdakoff. L'expansion scientifique Français, Paris 1966.Google Scholar
  3. 3.
    Haas, E., Goldblatt, H., Gipson, E. C., Lewis, L.: Extraction, purification, and assay of human renin free of angiotensinase. Circulat. Res.19, 739 (1966).Google Scholar
  4. 4.
    Haber, R., Koerner, T., Page, L. B., Kliman, B., Purnode, A.: Application of a radioimmunoassay for angiotensin I to the physiologic measurement of plasma renin activity in normal human subjects. J. clin. Endocr.29, 1349 (1969).Google Scholar
  5. 5.
    Osmond, D. H., Lewis, L. A., Smeby, R. R., Bumpus, F. M.: Renin “preinhibitor” in blood of anephric patients, in case of hypobetalipoproteinemia and evidence of its major association with plasma alpha lipoproteins. J. Lab. clin. Med.73, 809 (1969).Google Scholar
  6. 6.
    Ostrovsky, D., Sen, S., Smeby, R. R., Bumpus, F. M.: Chemical assay of phospholipid renin preinhibitor in canine and human plasma. Circulat. Res.21, 497 (1967).Google Scholar
  7. 7.
    Pickens, P. T., Bumpus, F. M., Lloyd, A. M., Smeby, R. R., Page, I. H.: Measurement of renin activity in human plasma. Circulat. Res.17, 438 (1965).Google Scholar
  8. 8.
    Rojo-Ortega, J. M., Genest, J. A.: A method for production of experimental hypertension in rats. Canad. J. Physiol. Pharmacol.46, 883 (1968).Google Scholar
  9. 9.
    Sen, S., Smeby, R. R., Bumpus, F. M.: Isolation of a phospholipid renin inhibitor from kidney. Biochemistry6, 1572 (1967).Google Scholar
  10. 10.
    Sen, S., Smeby, R. R., Bumpus, F. M.: Antihypertensive effect of an isolated phospholipid. Amer. J. Physiol.214, 337 (1968).Google Scholar
  11. 11.
    Sen, S., Smeby, R. R., Bumpus, F. M.: Plasma renin activity in hypertensive rats after treatment with renin preinhibitor. Amer. J. Physiol.216, 499 (1969).Google Scholar
  12. 12.
    Smeby, R. R., Sen, S., Bumpus, F. M.: A naturally occurring renin inhibitor. Circulat. Res.21 (Suppl. II), 129 (1967).Google Scholar

Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • A. Antonello
    • 1
  • B. Baggio
    • 1
  • S. Favaro
    • 1
  • A. Corsini
    • 1
  • S. Todesco
    • 1
  • A. Borsatti
    • 1
  1. 1.Istituto di Patologia Medica dell'Università di PadovaItalia

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