Summary
ProstaglandinsE 1,E 2,F 1α andF 2α injected into a lateral cerebral ventricle of the conscious sheep during exposure to various environmental conditions caused deep body temperature to rise. In a cool environment, faint shivering which was normally present became intensified and peripheral vasoconstriction became maximal. In a thermoneutral environment, shivering and vasoconstriction were elicited. In a warm environment, panting was markedly reduced and there was sometimes slight vasoconstriction. ProstaglandinsE 1 andE 2 were most effective,F 2α was slightly less, andF 1α considerably less effective. It was concluded that prostaglandins may be involved in transmission along brain neuronal pathways involved in the stimulation of heat production and increased peripheral vasomotor tone, and in the inhibition of heat loss mechanisms.
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Avery, D. D.: Thermoregulatory effects of intrahypothalamic injections of adrenergic and cholinergic substances at different environmental temperatures. J. Physiol. (Lond.)220, 257–266 (1972).
Barton, A. J., Bligh, J., Sharman, D. F.: Improved techniques for the chronic cannulation of the lateral cerebral ventricle and the cisterna magna of the Welsh Mountain sheep. J. Physiol. (Lond.)200, 25–27 P (1969).
Bligh, J.: Neuronal models of mammalian temperature regulation. In: Essays on temperature regulation, pp. 105–120. J. Bligh and R. E. Moore, edit. Amsterdam: North-Holland 1972.
Bligh, J., Cottle, W. H., Maskrey, M.: Influence of ambient temperature on the thermoregulatory responses to 5-hydroxytryptamine, noradrenaline and acetylcholine injected into the lateral cerebral ventricles of sheep, goats and rabbits. J. Physiol. (Lond.)212, 377–392 (1971).
Feldberg, W., Saxena, P. N.: Further studies on prostaglandin E1 fever in cats. J. Physiol. (Lond.)219, 739–745 (1971).
Findlay, J. D., Thompson, G. E.: The effects of intraventricular injections of noradrenaline, 5-hydroxytryptamine, acetylcholine and tranylcypromine on the ox (Bos taurus) at different environmental temperatures J. Physiol. (Lond.)194, 809–816 (1968).
Hales, J. R. S., Baird, J. A.: Effects of 5-hydroxytryptamine, noradrenaline, cholinomimetic substances and prostaglandinsE 1 andE 2 on thermoregulation in the echidna. Proc. intern. Union Physiol. Sci., in: Proc. Austr. physiol. pharmacol. Soc.3, no. 2, 172 (1972).
Hales, J. R. S., Hutchinson, J. C. D.: Metabolic respiratory and vasomotor responses to heating the scrotum of the ram. J. Physiol. (Lond.)212, 353–375 (1971).
Hedqvist, P.: Studies on the effect of prostaglandinsE 1 andE 2 on the sympathetic neuromuscular transmission in some animal tissues. Acta physiol. scand.79, Suppl. 345 (1970).
Holmes, S. W.: The spontaneous release of prostaglandins into the cerebral ventricles of the dog and the effect of external factors on this release. Brit. J. Pharmacol.38, 653–658 (1970).
Holmes, S. W., Horton., E. W.: The identification of four prostaglandins in dog brain and their regional distribution in the central nervous system. J. Physiol. (Lond.)195, 731–741 (1968).
Milton, A. S., Wendlandt, S.: Effects on body temperature of prostaglandins of theA, E andF series on injection into the third ventricle of unanesthetized cats and rabbits. J. Physiol. (Lond.)218, 325–336 (1971).
Myers, R. D., Yaksh, T. L.: Control of body temperature in the unanaesthetized monkey by cholinergic and aminergic systems in the hypothalamus. J. Physiol. (Lond.)202, 483–500 (1969).
Potts, W. J., East, P. F.: Effects of prostaglandinE 2 on the body temperature of conscious rats and cats. Arch. int. Pharmacodyn.197, 31–36 (1972).
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Hales, J.R.S., Bennett, J.W., Baird, J.A. et al. Thermoregulatory effects of prostaglandinsE 1,E 2,F 1α andF 2α in the sheep. Pflugers Arch. 339, 125–133 (1973). https://doi.org/10.1007/BF00587179
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DOI: https://doi.org/10.1007/BF00587179