Pflügers Archiv

, Volume 353, Issue 4, pp 303–315 | Cite as

The activity of respiratory neurons before and during panting in the cat

  • K. Pleschka
  • S. C. Wang
Article

Summary

The effects of heating the preoptic/anterior hypothalamic (PO/AH) region on medullary respiratory neurons were studied in urethane-anesthetized, spontaneously breathing cats. The efferent phrenic nerve discharge or the pneumotachogram served as an indicator of central respiratory periodicity.

In each animal, heating of the PO/AH area caused panting, defined as an increase of respiratory rate over 100 breaths per minute. During polypnea similar changes in the discharge patterns of both inspiratory and expiratory neurons were observed. There was a significant decrease in the duration of the discharge phase and the number of impulses per burst so that a reciprocal relationship existed between these parameters and respiratory rate. However, the average impulse frequency within a burst was higher during panting and could be shown to be a linear function of respiratory rate. Due to the concomitant decrease in inspiration and expiration times, the average discharge frequency per cycle time also increased in both inspiratory and expiratory medullary neurons. For continuously discharging neurons which displayed a higher frequency during the inspiration period (frequency modulated discharge), the phasic linkage remained unchanged during polypneic panting. From our results it is concluded that local heating of the PO/AH region shifts the entire respiratory system to a higher level of activity which can be correlated with ventilatory changes during panting.

Key words

Medullary Respiratory Neurons Local Hypothalamic Heating Controll of Respiratory Rate Panting 

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References

  1. Albers, C.: Der Mechanismus des Wärmehechelns beim Hund. I. Die Ventilation und die arteriellen Blutgase während des Wärmehechelns. Pflügers Arch. ges. Physiol.274, 125–147 (1961)Google Scholar
  2. Batsel, H. L.: Localization of bulbar respiratory centers by microelectrode sounding. Exp. Neurol.9, 410–426 (1964)Google Scholar
  3. Baumgarten, R. V., Nakayama, S.: Spontane und reizbedingte Änderungen der antidromen Erregbarkeit von bulbären respiratorischen Nervenzellen der Katze. Pflügers Arch. ges. Physiol.281, 245–258 (1964)Google Scholar
  4. Berman, A. L.: The brain stem of the cat. A cytoarchitectonic atlas with stereotaxic coordinates. Madison, Milwaukee-London: Univ. of Wisconsin Press 1968Google Scholar
  5. Cohen, M. I.: How respiratory rhythm originates: evidence from discharge patterns of brainstem respiratory neurones. Ciba Foundation Hering-Breuer Centenary Symposium: Breathing, pp. 125–157, ed. by R. Porter London: J. & A. Churchill, 1970Google Scholar
  6. Eklund, G., Euler, C. v., Rutkowski, S.: Spontaneous and reflex activity of intercostal gamma motoneurones. J. Physiol. (Lond.)171, 139–163 (1964)Google Scholar
  7. Engelhorn, R., Weller, E.: Aktionspotentiale atmungssynchron entladener Neurone der Medulla oblongata beim Husten. Pflügers Arch. ges. Physiol.273, 614–635 (1961)Google Scholar
  8. Euler, C. v., Herrero, F., Wexler, I.: Control mechanisms determining rate and depth of respiratory movements. Respir. Physiol.10, 93–108 (1970)Google Scholar
  9. Gill, P. K., Kuno, M.: Excitatory and inhibitory actions on phrenic motoneurons. J. Physiol. (Lond.)168, 274–289 (1963)Google Scholar
  10. Haber, E., Kohn, K. W., Ngai, S. H., Holaday, D. A., Wang, S. C.: Localization of spontaneous respiratory neuronal activities in the medulla of the cat: a new location of the expiratory center. Amer. J. Physiol.190, 350–355 (1957)Google Scholar
  11. Hammel, H. T., Hardy, J. D., Fusco, M. M.: Thermoregulatory response of hypothalamic cooling in unanaesthetized dogs. Amer. J. Physiol.198, 481–486 (1960)Google Scholar
  12. Hilaire, G., Monteau, R.: Activité des motoneurones phréniques au cours de la polypnée thermique ou hypocapnique. J. Physiol (Paris)68, 193–203 (1974)Google Scholar
  13. Karczewski, W. A., Karczewska, E., Rycembel, Z.: Thermal polypnea: Response of phrenic nerve activity to hyperthermia and hyperventilation. IRCS (73-8) (12-1-10) International Research Communications System 1973Google Scholar
  14. Lilienthal, J. L., Otenasek, F. J.: Decorticate polypneic panting in the cat. Bull. Johns Hopk. Hosp.61, 101–124 (1937)Google Scholar
  15. Magoun, H. W., Harrison, F., Brobeck, J. R., Ranson, S. W.: Activation of heat loss mechanisms by local heating of the brain. J. Neurophysiol.1, 101–114 (1938)Google Scholar
  16. Murakami, N., Stolwijk, J. A. J., Hardy, J. D.: Responses of preoptic neurons to anesthetics and peripheral stimulation. Amer. J. Physiol.213, 1015–1024 (1967)Google Scholar
  17. Nelson, J. R.: Single unit activity in medullary respiratory centers of cat. J. Neurophysiol.22, 590–598 (1959)Google Scholar
  18. Pitts, R. F.: Organization of the respiratory center. Physiol. Rev.26, 609–630 (1946)Google Scholar
  19. Pitts, R. F.: Excitation and inhibition of phrenic motoneurones. J. Neurophysiol.5, 75–88 (1942), cited in: Gauer, Kramer, Jung (eds.): Physiologie des Menschen 6, p. 196. München-Berlin-Wien: Urban & Schwarzenberg 1972Google Scholar
  20. Pleschka, K.: Der Einfluß der Temperatur auf die elektrische Aktivität des Nervus phrenicus. Untersuchungen am aufgeschnittenen Regelkreis. II. Hyperthermie. Pflügers Arch.308, 357–381 (1969)Google Scholar
  21. Price, W. M., Batsel, H. L.: Respiratory neurons participating in sneeze and in response to resistance in expiration. Exp. Neurol.29, 554–570 (1970)Google Scholar
  22. Salmoirhaghi, G. C., Delisle Burns, B.: Notes on mechanisms of rhythmic respiration. J. Neurophysiol.23, 14–26 (1960)Google Scholar
  23. Sears, T. A.: Efferent discharges in alpha and fusimotor fibres of intercostal nerves of the cat. J. Physiol. (Lond.)174, 295–315 (1964)Google Scholar
  24. Steel, R. G. D., Torrie, J. H.: Principles and procedure of statistics. New York-Toronto-London: McGraw-Hill 1960Google Scholar
  25. Wang, S. C., Ngai, S. H.: General organization of central respiratory mechanism, pp. 487–505. In: Handbook of physiology, Sec. 3, Respiration, ed. by W. O. Fenn and H. Rahn. Amer. Physiol. Soc. Washington 1964Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • K. Pleschka
    • 1
    • 2
  • S. C. Wang
    • 1
  1. 1.Department of Pharmacology, College of Physicians and SurgeonsColumbia UniversityNew York CityU. S. A.
  2. 2.Max-Planck-Institut für Physiologische und Klinische ForschungW. G. Kerckhoff-InstitutBad NauheimFederal Republic of Germany

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