Summary
The deformability of single red cells transformed by bile and rattle snake venom into smooth normovolemic spheres was measured with a glass capillary (l=10 μ,d=3–4 μ). Since the capillary was a part of an electrical circuit, red cells passing through the capillary changed the resistance, thus producing differently shaped spikes. It was shown that sphered red cells needed a greater length of time to pass through than normal ones, which is explained by lowered deformability. Chlorpromazine restored the flow to normal and improved the cell shape.
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Supported by the Deutsche Forschungsgemeinschaft.
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Braasch, D. Deformability and traversing time of shape-transformed single red cells passing through a 4 μ glass-capillary. Pflugers Arch. 329, 167–171 (1971). https://doi.org/10.1007/BF00586990
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DOI: https://doi.org/10.1007/BF00586990