Summary
The escape-phenomenon was simultaneously investigated in the vascular beds of intestine and kidney of the cat under conditions of constant flow perfusion. Constrictions were induced either by nerval stimulation (4–6 Hz, 0.5–1.5 msec, 2.5–8 V) or by infusion of noradrenaline (local concentration 0.347 and 0.320 μg/ml, respectively).
During electrical stimulation the escape in the intestinal circulation amounted to 77.8±1.7 [%], meaning that nearly 3/4 of the initial constriction vanished under the stimulation, which lasted 3.3 min in the mean. In the renal circulation the escape amounted to 81.1±1.7[%], the two values were not significantly different (n=2×82,P>0.1).
During humoral induction of the constrictions, the intestinal vascular bed showed an escape of 53.0±2.5[%], the renal circulation one of only 23.8±1.7[%] considering all results with escape (n=2×82,P<0,001). The phenomenon appeared in the intestinal vascular bed in 90.0% (n=90), in the renal vascular bed only in 67.8% (n=118) of all examinations. Including all values with and without perceptible escape the difference in the strength of escape in both circulations would be still more obvious.
The results demonstrate on the one hand a significant difference between nerval and humoral induction of the constriction in both investigated vascular beds. On the other hand under humoral treatment they show a distinct degree of organ specifity. Both statements are in accordance with the concept that the escape depends widely on a high and equal velocity in arrival of transmitter causing an initial synchronisation or matching in the activity of smooth muscle cells. Finally, after the in situ seen reactions (Fig. 3) there can be no doubt in the existence of an humoral induced escape in the renal circulation.
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Lutz, J., Henrich, H. Vergleich des vasculären Escape-Phänomens an der intestinalen und renalen Strombahn bei nervaler sowie humoraler Auslösung. Pflugers Arch. 339, 37–48 (1973). https://doi.org/10.1007/BF00586980
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DOI: https://doi.org/10.1007/BF00586980