Summary
Some of the factors which influence the shape of left ventricular isometric pressure are discussed. Complete isometric recordings were obtained in dogs by raising the afterload (aortic pressure) with a special blood pump of own design. The effects of ventricular geometry, myocardial wall thickness and finite velocity of the depolarization wave are discussed. The relation between active state of muscle fibers and isometrically developed pressure in the left ventricle is derived analytically. The commonly used velocity of the contractile element was computed in a new way by differentiation of logarithmically transformed pressure data. This derived function is compared with the simple derivative (dp/dt) with regard to their potential value as indices of myocardial contractility. Contractile element velocity as based on a 3-component model was not found sensitive to so-called contractility changes in the intact heart.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Brady, A. J.: Three element model of muscle mechanics: Its applicability to cardiac muscle. Physiologist10, 75 (1967).
Braunwald, E., Ross, J., Sonnenblick, E. H.: Mechanisms of contraction of the normal and failing heart. Boston: Little, Brown and Co. 1968.
Fung, Y. C.: Mathematical representation of the mechanical properties of the heart muscle. J. Biochem.3, 381–404 (1970).
Geivers, H., Schaper, W. K. A.: Ein neues transistorisiertes, elektromagnetisches Flowmeter nach dem Square-wave-Prinzip. Z. Kreisl.-Forsch.54, 1189 (1965).
Grimm, A. F., Katele, K. V., Kubata, R., Whitehorn, V. V.: Relation of sarcomere length and muscle length in resting myocardium. Amer. J. Physiol.218, 1412–1416 (1970).
Hill, A. V.: Abrupt transition from rest to activity in muscle. Proc. roy. Soc. B.136, 399 (1970).
Hugenholtz, P. G., Ellison, R. C., Urschel, C. W., Mirsky, I., Sonnenblick, E. H.: Myocardial force-velocity relationships in clinical heart disease. Circulation41, 191–202 (1970).
Iwazumi, T.: Ph. D. Thesis, Moore School of Electrical Engineering. (Penn.) (1970).
Janssen, P. A. J.: Piritramide (R3365), a potent analgesic with unusual chemical structure. J. Pharm. Pharmacol.13, 513–530 (1961).
—: The pharmacology of Haloperidol. Int. J. Neuropsychiat.3, 10–18 (1967).
Krayenbühl, H. P.: Die Dynamik und Kontraktilität des Linken Ventrikels. Bibl. cardiol.23, 1–183 (1969).
Lewi, P. J., Chandler, A. E. F.: Computer procedures for evaluating the results of studies on the distribution and metabolism of drugs in the body. Drug. Res.20, 684–693 (1970).
Pollack, G. H.: Maximum velocity as an index of contractility in cardiac muscle. Circulat. Res.26, 11–127 (1970).
Rushmer, R. F.: In: Cardiovascular dynamics, p. 47. Philadelphia: W. D. Saunders 1961.
Savitsky, A., Golay, M. J.: Smoothing and differentiation of data by simplified least squares procedures. Analyt. Chem.36, 1627–1639 (1964).
Schaper, W. K. A., Lewi, P., Jageneau, A. H. M.: The determinants of the rate of change of the left ventricular pressure (dp/dt). Arch. Kreisl.-Forsch.46, 27–41 (1965).
—, Rens, W., Jageneau, A. H. M.: Konstruktion und Eigenschaften neuer Meßköpfe zur elektromagnetischen Registrierung der Blutströmung. Pflügers Arch. ges. Physiol.283, 242 (1965).
Scher, A.: In: Cardiovascular Dynamics, p. 247. Ed. R. F. Rushmer. Philadelphia: Saunders 1961.
Sonnenblick, E. H.: Force-velocity relations in mammalian heart muscle. Amer. J. Physiol.202, 931–939 (1962).
—: Active state in heart muscle: Its delayed onset and modification by inotropic agents. J. gen. Physiol.50, 661 (1967).
Sonnenblick, E. H., Braunwald, E., Morrow, A. G.: The contractile properties of human heart muscle: studies on myocardial mechanics of surgically excised papillary muscles. J. clin. Invest.44, 966–977 (1965).
Ross, J., Covell, J. W., Sonnenblick, E. H., Braunwald, E.: Contractile state of the heart characterized by force-velocity relations in variably afterloaded and isovolumic beats. Circulat. Res.18, 149–163 (1966).
Taylor, R. R.: Active length-tension relations compared in isometric, afterloaded and isotonic contractions of cat papillary muscle. Circulat. Res.26, 279–288 (1970).
Van Der Meer, J. J.: Unpublished results (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lewi, P.J., Schaper, W.K.A. & Jageneau, A.H.M. Analysis of the isovolumic pressure in the canine left ventricle. Pflugers Arch. 329, 9–22 (1971). https://doi.org/10.1007/BF00586897
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00586897