Summary
The behaviour of the complement and of its components C4 and C3 has been studied in serum and in blister fluid both in patients with pemphigus vulgaris and other bullous dermatoses and in healthy subjects with experimentally induced blisters.
The results are suggestive of local activation of the complement, in the blister fluid of patients with pemphigus vulgaris, pemphigus erythematosus and bullous pemphigoid according to the classical enzymatic sequence.
Zusammenfassung
Die Aktivität von Komplement, insbesondere der C3-und C4-Komponenten wurde im Serum und im Blaseninhalt bei Patienten mit Pemphigus vulgaris und anderen bullösen Dermatosen sowie bei gesunden Kontrollpersonen mit experimentell ausgelösten Blasen untersucht.
Die Ergebnisse sprechen für eine lokale Aktivierung von Komplement im Sinne der klassischen Enzymsequenz bei Patienten mit Pemphigus vulgaris, Pemphigus erythematosus und beim bullösen Pemphigoid.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cormane, R. H., Chorzelski, T. P.: Bound complement in the epidermis of patients with pemphigus vulgaris. Dermatologica (Basel)134, 463–466 (1967)
Cram, D. L., Fukuyama, K.: Immunohistochemistry of ultraviolett-induced pemphigus and pemphigoid lesions. Arch. Derm.106, 819–824 (1972)
Jordon, R. E., Sams, W. M. Jr., Beutner, E. H.: Complement immunofluorescent staining in bullous pemphigoid. J. Lab. clin. Med.74, 548–556 (1969)
Jordon, R. E., Sams, W. M. Jr, Diaz, G., Beutner, E. H.: Negative complement immunofluorescence in pemphigus. J. invest. Derm.56, 407–410 (1971)
Jordon, R. E., Triftshauser, C. T., Schroeter, A. L.: Direct immunofluorescent studies of pemphigus and bullous pemphigoid. Arch. Derm.103, 486–491 (1971)
Jordon, R. E., Day, N. K., Luckasen, J. R., Good, R. A.: Complement activation in pemphigus vulgaris blister fluid. Clin. exp. Immunol.15, 53–63 (1973)
Jordon, R. E., Day, N. K., Sams, W. M. Jr, Good, R. A.: The complement system in bullous pemphigoid. I. Complement and component levels in sera and blister fluids. J clin. Invest.52, 1207–1214 (1973)
Jordon, R. E., Schroeter, A. L., Rogers, R. S., Perry, H. O.: Classical and alternate pathway activation of complement in pemphigus vulgaris lesions. J. invest. Derm.63 256–259 (1974)
Mancini, G., Carbonara, A. O., Heremans, J. F.: Immunochemical quantitation of antigens by single radial immunodiffusion. Int. J. Immunochem.2, 235–254 (1965)
Mayer, M. M.: Procedure for titration of complement. Experimental Immunochemistry. Ed. E. A. Kabat, M. M. Mayer, p. 163. Springfield. Ill.: Ch. Thomas 1961
Provost, T. T., Tomasi, T. B. Jr.: Evidence for complement activation via the alternate pathway in skin diseases. I. Herpes gestationis, systemic lupus erythematosus and bullous pemphigoid. J. clin. Invest.52, 1779–1787 (1973)
Provost, T. T., Tomasi, T. B. Jr: Immunopathology of bullous pemphigoid. Basement membrane deposition of IgE, alternate pathway components and fibrin. Clin. exp. Immunol.18, 193–200 (1974)
Van Joost, T., Cormane, R. H., Pondman, K. W.: Direct immunofluorescent study of the skin on occurrence of complement in pemphigus. Brit. J. Derm.87, 466–474 (1972)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sbano, E., Auteri, A., Fimiani, M. et al. Complement in pemphigus vulgaris and other bullous dermatoses. Arch. Derm. Res. 254, 143–148 (1975). https://doi.org/10.1007/BF00586889
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00586889