Summary
Anesthetized rabbits were submitted to thoracic compression and decompression in a body plethysmograph. Artificial ventilation with a positive-negative-pressure respirator via tracheal cannulation was performed, the mean inflation pressure being below, at or above atmospheric pressure. The static compliance of lungs and thorax was determined.
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a)
Therelaxation pressure curve in curarized animals was characterized by greater compliance with increasing lung distension. This effect was more pronounced in the case of artificial positive pressure ventilation than in the case of lowered perithoracic pressure.
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b)
Thepressure breathing curve exhibited a greater compliance in the vagotomized animal in thoracic compression. After vagotomy a marked and persistent rise of the lung volume was observed. Evidence suggests that in thoracic compression the vagal reflex is inspiratory.
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c)
Thevolume-pressure curve in the artificially ventilated non-curarized animal demonstrated a greater compliance in the positive pressure range compared to pressure breathing. At a pressure of 0 to 10 cm H2O, vagotomy resulted in a further increase in lung volume. These results suggest that in this range of positive pressure the vagal reflex is expiratory. Artificial positive pressure ventilation is a more efficient stimulus for the expiratory vagal reflex than lung distension by thoracic decompression.
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Die Untersuchungen wurden in verdankenswerter Weise unterstützt durch die Sandoz-Stiftung zur Förderung der medizinisch-biologischen Forschung und durch die Freiwillige Akademische Gesellschaft der Stadt Basel. Herrn Prof. O. A. M. Wyss vom Physiologischen Institut der Universität Zürich sei für die Überlassung des Plethysmographen gedankt.
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Fallert, M. Der hering-Breuer-Reflex bei künstlicher Beatmung des Kaninchens. Pflugers Arch. 338, 43–56 (1972). https://doi.org/10.1007/BF00586854
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DOI: https://doi.org/10.1007/BF00586854