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Prostaglandin D2 (PGD2) — A potent coronary vasoconstrictor agent in the guinea pig isolated heart

  • K. Schrör
Article

Summary

The action of prostaglandin D2 (PGD2) on myocardial force of contraction (MFC) and coronary vascular resistance (CVR) was studied in the isovolumetrically perfused guinea pig heart at constant driving frequency (180 beats/min). PGD2 (2·10−9–1·10−6 M) produced a concentration-dependent increase in the CVR while the MFC remained unchanged. The ED50 (50% of maximum response) of the coronary vasomotor action amounted to 4.3 ·10−8 M PGD2. The results give evidence for a potent coronary vasoconstrictor activity of PGD2.

Key words

Isolated guinea pig heart Coronary vascular resistance Myocardial force of contraction Prostaglandin D2 (PGD2

References

  1. Flower, R. J., Vane, J. R.: Some pharmacologic and biochemic aspects of prostaglandin biosynthesis and its inhibition. In: Prostaglandin Synthetase Inhibitors (H. J. Robinson, J. R. Vane, eds.), pp. 9–18. New York: Raven Press 1974Google Scholar
  2. Hamberg, M., Hedqvist, P., Strandberg, K., Svensson, J., Samuelsson, B.: Prostaglandin endoperoxides. IV. Effects on smooth muscle. Life Sci.16, 451–462 (1975)Google Scholar
  3. Jones, R. L.: Cardiovascular actions of prostaglandins D and E in the sheep: evidence for two distinct receptors. In: Advances in prostaglandin and Thromboxane Research, Vol. I, pp. 221–230 (B. Samuelsson, R. Paoletti, eds.). New York: Raven Press 1976Google Scholar
  4. Krebs, R., Schrör, K.: Actions of prostaglandin E2 on myocardial mechanics, coronary vascular resistance and oxygen consumption in the guinea pig isolated heart preparation. Br. J. Pharmacol.55, 403–408 (1975)Google Scholar
  5. Levi, R., Allan, G., Zavecz, J. H.: Prostaglandins and cardiac anaphylaxis. Life Sci.18, 1255–1264 (1976)Google Scholar
  6. Liebig, R., Bernauer, W., Peskar, B. A.: Prostaglandins, slow reacting substance and histamine release from anaphylactic guinea pig hearts and its pharmacological modification. Naunyn-Schmiedeberg's Arch. Pharmacol.289, 65–76 (1975)Google Scholar
  7. Needleman, P.: The synthesis and function of prostaglandins in the heart. Fed. Proc.35, 2376–2381 (1976)Google Scholar
  8. Schrör, K., Krebs, R.: Prostaglandin A2 (PGA2) increases the coronary vascular resistance in the guinea pig isolated heart preparation. Experientia33, 349 (1977)Google Scholar
  9. Schrör, K., Moncada, S., Ubatuba, F. B., Vane, J. R.: Transformation of arachidonic acid and prostaglandin endoperoxides by the guinea pig heart. Formation of RCS and prostacyclin. Eur. J. Pharmacol.47, 103–114 (1978)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • K. Schrör
    • 1
  1. 1.Pharmakologisches Institut der Universität KölnKöln 41Germany

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