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Control by insulin of sodium potassium and water excretion by the isolated dog kidney


Insulin has been shown to decrease sodium, potassium and water excretion by direct action on the kidney. Reduction of sodium excretion is due to enhanced tubular reabsorption as a probable consequence of stimulated active sodium transport. The renal effect of insulin is demonstrated with plasma hormone concentration observable in pathophysiological conditions; it offers therefore a possible explanation for some clinical findings such as the changes in sodium, potassium and water excretion occurring in man after fasting and subsequent glucose feeding.

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Nizet, A., Lefebvre, P. & Crabbé, J. Control by insulin of sodium potassium and water excretion by the isolated dog kidney. Pflugers Arch. 323, 11–20 (1971).

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  • Insulin
  • Sodium Excretion
  • Potassium Excretion
  • Water Excretion
  • Isolated Kidney


  • Insulin
  • Natriumexkretion
  • Kaliumexkretion
  • Wasser-exkretion
  • Isolierte Niere