Advertisement

Pflügers Archiv

, Volume 308, Issue 3, pp 185–196 | Cite as

Coronary circulation response to hyperoxia after vagotomy and combined alpha and beta adrenergic receptors blockade in the anesthetized intact dog

  • J. Lammerant
  • C. De Schryver
  • I. Becsei
  • M. Camphyn
  • J. Mertens-Strijthagen
Article

Summary

In closed-chest vagotomized dogs with alpha and beta adrenergic receptors blockade, ventilation with 100 per cent oxygen at atmospheric pressure did not modify the tension-time index nor the myocardial oxygen consumption. However, coronary blood flow decreased and coronary resistance increased significantly. A rise of the myocardialpO2 was not likely to be primarily responsible for the elevation of the coronary resistance. Since in the presence of a fixed oxygen consumption the myocardialpO2-elevation would occur following the rise of the arterialpO2 whose direct effect on the vascular smooth muscle tone has been demonstratedin vitro by other workers, it may be concluded that elevation of arterialpO2 exerted a direct constrictive action on the coronary vessels.

However, oxygen transport to the left ventricle remained commensurate to the myocardial oxygen consumption. It is suggested that an additional mechanism adjusted the elevated coronary resistance. Shifts of the myocardialpO2, resulting from transient imbalances between oxygen supply and demand, may be the stimulus initiating the adjustment through changing release of vasodilator or vasoconstrictor substances.

Results of this paper and those previously published indicated that autonomic influences normally play a dominant role in the hyperoxia-induced reduction in cardiac work and metabolism.

Key-Words

Blood Oxygen Tension Coronary Blood Flow Coronary Resistance Myocardial Oxygen Consumption Adrenergic Receptors Blockade 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bassingthwaighte, J. B., T. Strandell, andD. E. Donald: Estimation of coronary blood flow by washout of diffusible indicators. Circulat. Res.23, 259–278 (1968).Google Scholar
  2. 2.
    Bergofsky, E. H., andP. Bertun: Response of regional circulations to hyperoxia. J. appl. Physiol.21, 567–572 (1966).Google Scholar
  3. 3.
    Berne, R. M.: Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Amer. J. Physiol.204, 317–322 (1963).Google Scholar
  4. 4.
    Carrier, O., Jr., J. R. Walker, andA. C. Guyton: Role of oxygen in autoregulation of blood flow in isolated vessels. Amer. J. Physiol.206, 951–954 (1964).Google Scholar
  5. 5.
    Daly, W. J., andS. Bondurant: Effects of oxygen breathing on the heart rate, blood pressure, and cardiac index of normal men, resting, with reactive hyperemia and after atropine. J. clin. Invest.41, 126–132 (1962).Google Scholar
  6. 6.
    Daniell, H. B., andE. E. Bagwell: Effects of high oxygen on coronary flow and heart force. Amer. J. Physiol.214, 1454–1459 (1968).Google Scholar
  7. 7.
    Dripps, R. D., andJ. H. Comroe, Jr.: The effect of the inhalation of high and low oxygen concentrations on respiration, pulse rate, ballistocardiogram and arterial oxygen saturation (oximeter) of normal individuals. Amer. J. Physiol.149, 277–291 (1947).Google Scholar
  8. 8.
    Eckenhoff, J. E., J. H. Hafkenschiel, andC. M. Landmesser: The coronary circulation in the dog. Amer. J. Physiol.148, 582–596 (1947).Google Scholar
  9. 9.
    ——— andM. Harmel: Cardiac oxygen metabolism and control of the coronary circulation. Amer. J. Physiol.149, 634–649 (1947).Google Scholar
  10. 10.
    Eggers, G. W. N., Jr., H. W. Paley, J. J. Leonard, andJ. V. Warren: Hemodynamic responses to oxygen breathing in man. J. appl. Physiol.17, 75–79 (1962).Google Scholar
  11. 11.
    Hale, H. B., E. W. Williams, J. E. Anderson, andJ. P. Ellis, Jr.: Endocrine and metabolic effects of short-duration hyperoxia. Aerospace Med.35, 449–451 (1964).Google Scholar
  12. 12.
    Herd, J. A., M. Hollenberg, G. D. Thorburn, H. H. Kopald, andA. C. Barger: Myocardial blood flow determined with krypton 85 in unanesthetized dogs. Amer. J. Physiol.203, 122–124 (1962).Google Scholar
  13. 13.
    Katori, M., andR. M. Berne: Release of adenosine from anoxic hearts. Relationship to coronary flow. Circulat. Res.19, 420–425 (1966).Google Scholar
  14. 14.
    Kirk, E. S., andC. R. Honig: Nonuniform distribution of blood flow and gradients of oxygen tension within the heart. Amer. J. Physiol.207, 661 to 668 (1964).Google Scholar
  15. 15.
    Lammerant, J., C. De Schryver, I. Becsei, andJ. Mertens-Strijthagen: Response of the coronary circulation to hyperoxia in the anesthetized intact dog. Arch. int. Pharmacodyn.173, 244–253 (1968).Google Scholar
  16. 16.
    Meijne, N. G., andJ. P. Straub: Coronary sinus blood flow during oxygen ventilation at 1 ATA and 3 ATA. Dis. Chest50, 161–172 (1966).Google Scholar
  17. 17.
    Moss, A. J.: Intramyocardial oxygen tension. Cardiovasc. Res.2, 314–318 (1968).Google Scholar
  18. 18.
    Nayler, W. G., J. M. Price, andT. E. Lowe: Inhibition of adenosine-induced coronary vasodilatation. Cardiovasc. Res.1, 63–66 (1967).Google Scholar
  19. 19.
    Ross, R. S., K. Ueda, P. R. Lichtlen, andJ. R. Rees: Measurement of myocardial blood flow in animals and man by selective injection of radioactive inert gas into the coronary arteries. Circulat. Res.15, 28–41 (1964).Google Scholar
  20. 20.
    Sarnoff, S. J., E. Braunwald, G. H. Welch, Jr., R. B. Case, W. N. Stainsby, andR. Macruz: Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension-time index. Amer. J. Physiol.192, 148–156 (1958).Google Scholar
  21. 21.
    Share, L.: Personal communication (1958).Google Scholar
  22. 22.
    Smith, D. J., andJ. R. Vane: Effects of oxygen tension on vascular and other smooth muscle. J. Physiol. (Lond.)186, 284–294 (1966).Google Scholar
  23. 23.
    Sobol, B. J., S. A. Wanlass, E. B. Joseph, andI. Azarshahy: Alteration of coronary blood flow in the dog by inhalation of 100 per cent oxygen. Circulat. Res.11, 797–802 (1962).Google Scholar
  24. 24.
    Vander, A. J.: Personal communication (1968).Google Scholar

Copyright information

© Springer-Verlag 1969

Authors and Affiliations

  • J. Lammerant
    • 1
  • C. De Schryver
    • 1
  • I. Becsei
    • 1
  • M. Camphyn
    • 1
  • J. Mertens-Strijthagen
    • 1
  1. 1.Department of PhysiologyThe Facultés Universitaires Notre Dame de la Paix Medical SchoolNamurBelgium

Personalised recommendations