Summary
The arterial and venous oxygen parameters were measured during 3 h in fifteen air-ventilated dogs injected intraperitoneally (100 ml/kg) with different solutions. Three groups were studied: 1. control (C); 2. water depleted (WD); 3. water and salt depleted (WSD).
The WSD showed lower mixed venous O2 content, saturation and pH and greater (A-V) O2 rate of change than the WD. Comparable\(P_{\upsilon {\text{o}}_2 } \) changes were recorded. About half of these modifications could be explained on the basis of the increased intra-abdominal pressure with resulting venostasis (Jach, Marotta and Marbarger, 1959).
The plasma volume decrease, comparable in the WD and WSD, accounts for the largest changes observed in the oxygen parameters probably due to the resulting decrease in cardiac output and low blood flow in these animals. The Bohr effect might explain why in spite of comparable\(P_{{\text{o}}_3 } \) values the mixed venous O2 content and saturation, and arterial hemoglobin O2 saturation values are lower in WSD than in WD.
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This work was partially presented at the “III Jornadas Uruguayas de Ciencias Fisiológicas”, Montevideo, 15–17 December, 1972. Uruguay.
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Libermann, I.M., Pierce, H.G. Time course of arteriovenous oxygenation in dogs acutely depleted of water and of water and salt. Pflugers Arch. 348, 115–125 (1974). https://doi.org/10.1007/BF00586474
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DOI: https://doi.org/10.1007/BF00586474