Summary
Activity of Na−K-ATPase from foetal rat kidney, very low on days 17 and 18 of gestation, increases from day 19. This rise does not occur when maternal and foetal sources of adrenal steroids are supressed by mothers' adrenalectomy and Metopirone administration. In foetuses from adrenalectomized-Metopirone treated mothers, Aldosterone restores the Na−K-ATPase activity to its normal level.
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This research was supported by a grant from the Délégation Générale à la Recherche Scientifique et Technique (72.7.0580).
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Geloso, JP., Basset, JC. Role of adrenal glands in development of foetal rat kidney Na−K-ATPase. Pflugers Arch. 348, 105–113 (1974). https://doi.org/10.1007/BF00586473
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DOI: https://doi.org/10.1007/BF00586473