Pflügers Archiv

, Volume 345, Issue 3, pp 221–236 | Cite as

Die Wirkung aktiv transportierter Zucker auf den Natrium-, Kalium- und Volumentransport am Jejunum und Ileum der Ratte

  • R. Dennhardt
  • F. J. Haberich

The action of actively transported sugars on the sodium, potassium, and fluid transport in the jejunum and ileum of the rat


Perfusion experiments were carried out in the proximal jejunum and in the distal ileum of conscious rats, using a newly devised technique. The stimulation effect of actively transported hexoses on the sodium, potassium and fluid absorption is demonstrated.
  1. 1.

    There are quantitative differences concerning the effect of 3-O-methyl-d-glucose andd-glucose on the sodium and water absorption.

  2. 2.

    The stimulation by glucose can be seen only when the glucose concentration in the luminal fluid is greater than 10 mM.

  3. 3.

    The ratio of 3-O-methyl-d-glucose- to sodium-transfer-rate is >1, while it is exactly 1 in the experiments involvingd-glucose.

  4. 4.

    The sodium-water equivalent is isotonic under all experimental conditions.

  5. 5.

    In the presence of actively transported hexoses the secretion of potassium into an initially K+-free perfusate is significantly diminished.

  6. 6.

    The transport of potassium depends on the net fluid movement.

  7. 7.

    The stimulation of glucose and 3-O-methyl-d-glucose can only be demonstrated in the jejunum of rat whereas no effect is seen in the distal ileum and colon.

  8. 8.

    These results suggest that “solvent drag” isone factor which under the above mentioned experimental conditions affects the enhanced electrolyte and water absorption in the jejunum of the rat.


Key words

Intestinal Water and Electrolyte Absorption Effect of Actively Transported Hexoses Conscious Rats 


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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • R. Dennhardt
    • 1
  • F. J. Haberich
    • 1
  1. 1.Institut für Angewandte Physiologie der Philipps-Universität MarburgMarburg (Lahnberge)Germany

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