Summary
Genetic inheritance predisposing individuals to diabetes mellitus was discussed in this work group. The two forms of the disease, Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) were discussed separately since the pattern of inheritance and genes involved appear to be distinctly different. Within these subtypes there is considerable genetic heterogeneity, and superimposed environmental factors confound the analysis. New technologies that will allow finer molecular analysis, as well as new candidates genes, were presented.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Eisenbarth GS (1986) Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 314:1360–1368
Van D'Heim C, Rimoin DL, Rotter J (1990) In: Emery AEH, Rimoin DL (eds) Principles and practice of medical genetics II. Churchill Livingstone, New York
Krolewski AS, Warram JH, Rand LI, Kahn CR (1987) Epidemiologic approach to the aetiology of type I diabetes mellitus and its complications. N Engl J Med 317:1390–1392
Erlich HA (1990) HLA class II polymorphism and genetic susceptibility to insulin-dependent diabetes mellitus. Curr Top Microbiol Immunol 164:41–43
Acha-Orbea H, McDevitt HO (1990) The role of class II molecules in development of insulin-dependent diabetes mellitus in mice, rats and humans. Curr Top Microbiol Immunol 156:103–105
Shizuru JA, Sarvetnick N (1990) Transgenic mice for the study of diabetes mellitus. Trends Endocrin Metab 2:97–105
Todd JA, Aitman TJ, Comall RJ et al. (1991) Genetic analysis of autoimmune type I diabetes mellitus in mice. Nature 351:542–546
Bell GI, Xiang K-S, Newman MV et al. (1991) Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc Natl Acad Sci USA 88:1484–1488
Froguel Ph, Vaxillaire M, Sun F et al. (1992) Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature 356:167–164
Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR (1990) Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 113:909–921
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Weatherall, D., Sarvetnick, N. & Shizuru, J.A. Genetic control of diabetes mellitus. Diabetologia 35 (Suppl 2), S1–S7 (1992). https://doi.org/10.1007/BF00586273
Issue Date:
DOI: https://doi.org/10.1007/BF00586273