Pflügers Archiv

, Volume 350, Issue 2, pp 123–134 | Cite as

The effects of ambient and hypothalamic temperatures on the hyperthermic responses to prostaglandins E1 and E2

  • Tetsuro Hori
  • Yasuko Harada


The effects of ambient and hypothalamic temperatures were studied on the hyperthermic responses to prostaglandins E1 and E2 (PGE1 and PGE2) injected intraventricularly in the unanesthetized rabbit. Hyperthermic responses to PGE1 observed at different thermal environments were approximately equal in magnitude and time course. However, the prevailing ambient temperature influenced the thermoregulatory mechanisms by which the hyperthermia was achieved. In a hot environment, PGE1-hyperthermia was brought about by suppression of heat loss mechanism with little change in heat production. During cold exposure body temperature was raised mainly by an increase in heat production without a significant change in heat loss. PGEs-hyperthermias were attenuated by warming and enhanced by cooling the anterior hypothalamus. These changes in the hyperthermic responses to PGE1 and PGE2 are in contrast to those obtained with intraventricular injection of noradrenaline at different ambient temperatures and during hypothalamic heating and cooling. It is therefore unlikely that noradrenaline is involved in the hyperthermic responses to PGEs. On the other hand, the results support the view that prostaglandins may be mediators of pyrogen-induced fever.

Key words

Prostaglandins Hypothalamic Temperature Thermoregulation Fever Noradrenaline 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ambache, N., Brummer, H. C., Rose, J. G., Whiting, J.: Thin-layer chromatography of spasmogenic unsaturated hydroxyacids from various tissues. J. Physiol. (Lond.)185, 77–78P (1966)Google Scholar
  2. Andersen, H. T., Hammel, H. T., Hardy, J. D.: Modifications of the febrile response to pyrogen by hypothalamic heating and cooling in the unanesthetized dog. Acta physiol. scand.53, 247–254 (1961)Google Scholar
  3. Bligh, J., Cottle, W. H., Maskrey, M.: Influence of ambient temperature on the thermoregulatory responses to 5-hydroxytryptamine, noradrenaline and acetylcholine injected into the lateral cerebral ventricles of sheep, goats and rabbits. J. Physiol. (Lond.)212, 377–392 (1971)Google Scholar
  4. Bloom, F. E., Hoffer, B. J., Siggins, G. R.: Norepinephrine mediated cerebellar synapses: a model system for neuropsychopharmacology. Biol. Psychiat.4, 157–177 (1972)Google Scholar
  5. Cameron, I. R., Semple, S. J. G.: The central respiratory stimulant action of salicylates. Clin. Sci.35, 391–401 (1968)Google Scholar
  6. Cooper, K. E., Cranston, W. I., Honour, A. J.: Effects of intraventricular and intrahypothalamic injection of noradrenaline and 5-HT on body temperature in conscious rabbits. J. Physiol. (Lond.)181, 852–864 (1965)Google Scholar
  7. Corrodi, H., Fuxe, K., Hökfelt, T.: A possible role played by central monoamine neurones in thermoregulation. Acta physiol. scand.71, 224–232 (1967)Google Scholar
  8. Dahlström, A., Fuxe, K.: Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta physiol. scand., 62, Suppl.232, 1–55 (1964)Google Scholar
  9. Feldberg, W., Gupta, K. P.: Pyrogen fever and prostaglandin like activity in cerebrospinal fluid. J. Physiol. (Lond.)228, 41–53 (1973)Google Scholar
  10. Feldberg, W., Saxena, P. N.: Fever produced by prostaglandin E1. J. Physiol (Lond.)217, 547–556 (1971a)Google Scholar
  11. Feldberg, W., Saxena, P. N.: Further studies on prostaglandin E1 fever in cats. J. Physiol. (Lond.)219, 739–745 (1971b)Google Scholar
  12. Fuxe, K.: Evidence for the existence of monoamine neurones in the central nervous system. IV. Distribution of monoamine nerve terminals in the central nervous system. Acta physiol. scand. 64, Suppl.247, 37–85 (1965)Google Scholar
  13. Hales, J. R. S., Bennett, J. W., Baird, J. A., Fawcett, A. A.: Thermoregulatory effects of prostaglandins E1, E2, F and F in the sheep. Pflügers Arch.339, 125–133 (1973)Google Scholar
  14. Hedqvist, P.: Studies on the effect of prostaglandins E1 and E2 on the sympathetic neuromuscular transmission in some animal tissues. Acta physiol. scand.79, Suppl. 345 (1970)Google Scholar
  15. Holmes, S. W.: The spontaneous release of prostaglandins into the cerebral ventricles of the dog and the effect of external factors on this release. Brit. J. Pharmacol.38, 653–658 (1970)Google Scholar
  16. Holmes, S. W., Horton, E. W.: The identification of four prostaglandins in dog brain and their regional distribution in the central nervous system. J. Physiol. (Lond.)195, 731–741 (1968)Google Scholar
  17. Hori, T., Harada, Y.: Hyperthermic responses produced by intracerebral injections of prostaglandins E1 and E2 and noradrenaline. J. Physiol. Soc. Japan.35, 434–435 (1973)Google Scholar
  18. Hori, T., Nakayama, T., Goto, J.: Thermo-sensitive neurons in the hypothalamus and the midbrain in the rabbit: Their responses to monoamines applied by microiontophoresis. J. Physiol. Soc. Japan.34, 549 (1972)Google Scholar
  19. Hori, T., Nakayama, T.: Effects of biogenic amines on central thermo-responsive neurones in the rabbit. J. Physiol. (Lond.)232, 71–85 (1973)Google Scholar
  20. Lipton, J. M., Fosster, D. M.: Fever produced in the squirrel monkey by intravenous and intracranial injections ofS. Typhosa endotoxin. Physiologist16, 379 (1973)Google Scholar
  21. Maskrey, M., Bligh, J.: Interactions between the thermoregulatory responses to injections into a lateral cerebral ventricle of the Welsh mountain sheep of putative neurotransmitter substances, and of local changes in anterior hypothalamic temperature. Int. J. Biometeor.15, 129–133 (1971)Google Scholar
  22. Milton, A. S., Wendlandt, S.: Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanesthetized cats and rabbits. J. Physiol. (Lond.)218, 325–336 (1971)Google Scholar
  23. Palmes, E. D., Park, C. R.: The regulation of body temperature during fever. Arch. environm. Hlth11, 749–759 (1965)Google Scholar
  24. Sawyer, C. H., Everett, J. W., Green, J. D.: The rabbit diencephalon in stereotaxic coordinates. J. comp. Neurol.101, 801–824 (1954)Google Scholar
  25. Siggins, G., Hoffer, B., Bloom, F.: Prostaglandin-norepinephrine interactions in brain: microelectrophoretic and histochemical correlates. Ann. N. Y. Acad. Sci.180, 302–323 (1971)Google Scholar
  26. Vane, J. R.: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol.231, 232–235 (1971)Google Scholar

Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Tetsuro Hori
    • 1
  • Yasuko Harada
    • 1
  1. 1.Department of Physiology, Institute of Constitutional MedicineKumamoto UniversityKumamotoJapan

Personalised recommendations