Pflügers Archiv

, Volume 350, Issue 2, pp 123–134 | Cite as

The effects of ambient and hypothalamic temperatures on the hyperthermic responses to prostaglandins E1 and E2

  • Tetsuro Hori
  • Yasuko Harada
Article

Summary

The effects of ambient and hypothalamic temperatures were studied on the hyperthermic responses to prostaglandins E1 and E2 (PGE1 and PGE2) injected intraventricularly in the unanesthetized rabbit. Hyperthermic responses to PGE1 observed at different thermal environments were approximately equal in magnitude and time course. However, the prevailing ambient temperature influenced the thermoregulatory mechanisms by which the hyperthermia was achieved. In a hot environment, PGE1-hyperthermia was brought about by suppression of heat loss mechanism with little change in heat production. During cold exposure body temperature was raised mainly by an increase in heat production without a significant change in heat loss. PGEs-hyperthermias were attenuated by warming and enhanced by cooling the anterior hypothalamus. These changes in the hyperthermic responses to PGE1 and PGE2 are in contrast to those obtained with intraventricular injection of noradrenaline at different ambient temperatures and during hypothalamic heating and cooling. It is therefore unlikely that noradrenaline is involved in the hyperthermic responses to PGEs. On the other hand, the results support the view that prostaglandins may be mediators of pyrogen-induced fever.

Key words

Prostaglandins Hypothalamic Temperature Thermoregulation Fever Noradrenaline 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Tetsuro Hori
    • 1
  • Yasuko Harada
    • 1
  1. 1.Department of Physiology, Institute of Constitutional MedicineKumamoto UniversityKumamotoJapan

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