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Handling of uric acid by the rat kidney

III. Microperfusion studies on steady state concentration of euric acid in the proximal tubule. Consideration of free flow conditions

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Summary

In volume constant microperfusion experiments a steady state ratio of uric acid concentration in tubular fluid and plasma of aproximately 2.5 is found. An extrapolation to free flow conditions shows agreement with previous micropuncture results.

This finding supports the view that uric acid undergoes net secretion in the proximal tubule of the rat kidney. It is discussed that the low uric acid clearance of the intact kidney is mainly caused by uric acid reabsorption in the loop of Henle.

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Authors and Affiliations

  1. Institute of Physiology, University of Innsbruck, Innsbruck, Austria

    F. Lang, R. Greger & P. Deetjen

  2. Institute of Physiology, University of München, Münich, Germany

    F. Lang, R. Greger & P. Deetjen

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  1. F. Lang
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  2. R. Greger
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  3. P. Deetjen
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Lang, F., Greger, R. & Deetjen, P. Handling of uric acid by the rat kidney. Pflugers Arch. 338, 295–302 (1973). https://doi.org/10.1007/BF00586071

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  • DOI: https://doi.org/10.1007/BF00586071

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