Summary
The penetration of either “ionic” or “colloidal” lanthanum into the tight junctions of different tubular segments of the rat kidney was studied with the electron microscope. After perfusing the tracer through the aorta it was found that “ionic” and “colloidal” lanthanum penetrated the tight junctions of both the proximal and distal convoluted tubules, while the junctions of the collecting tubules were free of tracer. An attempt to correlate junctional tightness and electrical resistance in these epithelia is presented.
References
Erlij, D., Martínez-Palomo, A.: Opening of tight junctions in toad urinary bladders by hypertonic solutions. Fed. Proc.32, 218 (1973)
Farquhar, M. G., Palade, G. E.: Junctional complexes in various epithelia. J. Cell Biol.17, 375–412 (1963)
Frömter, E., Diamond, J.: Route of passive ion permeation in epithelia. Nature New Biol.235, 9–13 (1972)
Hegel, U., Frömter, E., Wick, T.: Der elektrische Wandwiderstand des proximalen Konvolutes der Rattenniere. Pflügers Arch. ges. Physiol.294, 274–290 (1967)
Helman, S. I., Grantham, J. J., Burg, M. B.: Effect of vasopressin on electrical resistance of renal cortical collecting tubules. Amer. J. Physiol.220, 1825–1832 (1971)
Karnovsky, M. J.: The ultrastructural basis of capillary permeability studied with peroxidase as a tracer. J. Cell Biol.35,213–236 (1967)
Leaf, A.: Transepithelial transport and its hormonal control in toad bladder. Ergebn. Physiol.56, 216–263 (1965)
Machen, T. E., Erlij, D., Wooding, F. B. P.: Permeable junctional complexes. The movement of lanthanum across rabbit gallbladder and intestine. J. Cell Biol.54, 302–312 (1972)
Malnic, G., Giebisch, G.: Some electrical properties of distal tubular epithelium in the rat. Amer. J. Physiol.223, 797–808 (1972)
Martínez-Palomo, A., Erlij, D., Bracho, H.: Detection of permeability barriers in frog skin epithelium. J. Cell Biol.50, 277–287 (1971)
Maunsbach, A. B., Christensen, E. I., Ottosen, P. D., Larsson, L.: Uptake, transport and digestion of proteins in kidney cells. Proc. Internat. Congr. Histochem. Cytochem., p. 65. New York: Mac Millan 1972
Revel, J. P., Karnovsky, M. J.: Hexagonal array of subunits in intercellular junctions of the mouse heart and liver. J. Cell Biol.33, C7-C12 (1967)
Smulders, A., Wright, E. M.: The magnitude of nonelectrolyte selectivity in the gall bladder epithelium. J. Membr. Biol.5, 297–318 (1971)
Tisher, C. C., Yarger, W. E.: Lanthanum permeability of the tight junction (zonula occludens) in the renal tubule of the rat.Kidney Internat.3, 238–250 (1973)
Whittembury, G., Rawlins, F. A.: Evidence of a paracellular pathway for ion flow in the kidney proximal tubule: electromicroscopic demonstration of lanthanum precipitate in the tight junction. Pflügers Arch.330, 302–309 (1971)
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Martínez-Palomo, A., Erlij, D. The distribution of lanthanum in tight junctions of the kidney tubule. Pflugers Arch. 343, 267–272 (1973). https://doi.org/10.1007/BF00586049
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DOI: https://doi.org/10.1007/BF00586049