Pflügers Archiv

, Volume 366, Issue 2–3, pp 137–142 | Cite as

Passive stress relaxation followed by active contracture in vertebrate smooth muscles (Taenia coli of the guinea pig)

  • B. Hohorst
  • U. Kröhnert
  • K. Greven
Article

Summary

  1. 1.

    The time course of stress relaxation following stretch was investigated in the taenia coli of the guinea pig in the relaxed (Ca2+ free bath solution with D 600) and in the contracted state (depolarization by KCl or K2SO4 in excess). The mechanical tension was standardized with respect to the volume of the samples.

     
  2. 2.

    The tension obtained by a constant stretch of 2.5 mm of the 5–15 mm samples was highest after K2SO4-depolarization (K+=180 mval/l) and lowest in the relaxed muscles. Muscles contracted by KCl in excess (K+=60 mval/l) showed intermediate values.

     
  3. 3.

    The decrease of tension by stress relaxation to a nearly constant residual value is rapidly observed in contracted muscles during about 10 s. For the relaxed muscles the same changes are slower and take place in nearly 1/2 h.

     
  4. 4.

    The relations between the extent of stress relaxation (R) and its derivative in time (dR/dt) can be expressed by a hyperbolic function. Analogous behaviour was already noted in previous studies primarily on creep.

     
  5. 5.

    The different behaviour of the muscle in the different bath solutions used is discussed with respect to the mathematical relations just mentioned.

     
  6. 6.

    Long term active reactions of depolarized muscles following stretch and stress relaxation are noted.

     

Key words

Smooth muscle Stress relaxation Creep Elasticity Depolarized muscle 

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References

  1. Bozler, E.: Plasticity of contractile elements as studied in extracted muscle fibres. Amer. J. Physiol.171, 359–364 (1952)Google Scholar
  2. Bozler, E.: Smooth and cardiac muscle in states of strong internal crosslinking and high permeability. Amer. J. Physiol.207, 701–704 (1964)Google Scholar
  3. Casteels, R., Kuriyama, H.: Membrane potential and ion content in the smooth muscle of the guinea-pig's taenia coli at different external potassium concentrations. J. Physiol. (Lond.)184, 120–130 (1966)Google Scholar
  4. Goodford, P. J., Hermansen, K.: Sodium and potassium movements in the unstriated muscle of the guinea pig taenia coli. J. Physiol. (Lond.)158, 426–488 (1961)Google Scholar
  5. Greven, K.: The time course of creep and stress relaxation in relaxed and contracted smooth muscles (taenia coli of the guinea pig). In: Physiology of smooth muscle (E. Bülbring and M. F. Shuba, eds.), pp. 223–228. New York: Raven Press 1976Google Scholar
  6. Greven, K., Gotthardt, H., Hancke, E.: Der zeitliche Verlauf von Nachdehnungserscheinungen (Nachdehnung und Relaxation) an der Taenia coli des Meerschweinchen unter verschiedenen Bedingungen. Pflügers Arch.344, 245–260 (1973)Google Scholar
  7. Greven, K., Hohorst, B.: Creep after loading in relaxed and contracted (KCl or K2SO4 depolarized) smooth muscle (taenia coli of the guinea pig). Pflügers Arch.359, 111–125 (1975)Google Scholar
  8. Greven, K., Rudolph, K. H., Hohorst, B.: Creep after loading in the relaxed and contracted smooth muscle (taenia coli of the guinea pig) under various osmotic conditions. Pflügers Arch.362, 255–260 (1976)Google Scholar
  9. Heinl, P.: Mechanische Aktivierung und Deaktivierung der isolierten kontraktilen Struktur des Froschsartorius durch rechteckförmige und sinusförmige Längenänderungen. Pflügers Arch.333, 213–226 (1972)Google Scholar
  10. Holman, M. E.: Membrane potentials recorded with high-resistance micro-electrodes; and the effects of changes in ionic environment on the electrical and mechanical activity of the smooth muscle of the taenia coli of the guinea pig. J. Physiol. (Lond.)141, 464–488 (1958)Google Scholar
  11. Jewell, B. R., Rüegg, J. C.: Oscillatory contraction of insect fibrillar muscle after glycerol extraction. Proc. roy. Soc. B164, 429–459 (1966)Google Scholar
  12. Jones, A. W., Somlyo, A. P., Somlyo, A. V.: Potassium accummulation in smooth muscle and associated ultrastructural changes. J. Physiol. (Lond.)232, 247–273 (1973)Google Scholar
  13. Mironneau, J.: Excitation-contraction coupling in voltage clamped uterine smooth muscle. J. Physiol. (Lond.)233, 127–141 (1973)Google Scholar
  14. Peiper, U., Laven, R., Regnat, K., Schmidt, E.: Mechanical response to stretch of depolarized vascular smooth muscle fibres. Basic Res. Cardiol.69, 1–10 (1974)Google Scholar
  15. Steiger, G. J.: Stretch activation and myogenic oscillation of isolated contractile structures of heart muscle. Pflügers Arch.330, 347–361 (1971)Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • B. Hohorst
    • 1
  • U. Kröhnert
    • 1
  • K. Greven
    • 1
  1. 1.Abteilung für Allgemeine Physiologie im Zentrum der Physiologie der Johann Wolfang Goethe-UniversitätFrankfurt/MainGermany

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