Pflügers Archiv

, Volume 345, Issue 4, pp 317–326 | Cite as

Transport of amino-acids and sugars by the dog colonic mucosa

  • J. W. L. Robinson
  • A. -L. Luisier
  • V. Mirkovitch


Dog colon mucosa is able to concentrate amino-acids and sugars against a concentration gradient during incubation in vitro. Amongst other species tested, this property is only shared, to any reasonable extent, by the mouse colon.

The properties of the dog colon transport systems have much in common with corresponding mechanisms in the small intestine (Na+-dependence, energy-dependeace, saturation kinetics), but their capacities are considerably lower.

The difference between species (rats, guinea-pigs, mice and humans) is probably quantitative rather than qualitative in nature, since entry into rat colon slices is affected by the absence of Na+ ions and inhibited by homologues.

Key words

Colonic Transport Dog Colon Amino-acid Transport Sugar Transport 


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  1. Baillien, M., Schoffeniels, E.: Le transport actif d'acides aminés au niveau de l'épithélium intestinal isolé de la tortue grecque. Biochim. biophys. Acta (Amst.)53, 521–536 (1961)Google Scholar
  2. Binder, H. J.: Amino acid absorption in the mammalian colon. Biochim. biophys. Acta (Amst.)219, 503–506 (1970)Google Scholar
  3. Cramer, F.: Papierchromatographie. Monographie Nr. 64 zu Angewandte Chemie und Chemie-Ingenieur-Technik, S. 38–52. Weinheim/Bergstr: Verlag-Chemie 1952Google Scholar
  4. Evered, D. F., Nunn, P. B.: Uptake of amino acids by mucosa of rat colon in vitro. Europ. J. Biochem.4, 301–304 (1968)Google Scholar
  5. Goldner, A. M., Schultz, S. G., Curran, P. F.: Sodium and sugar fluxes across the mucosal border of rabbit ileum. J. gen. Physiol.53, 362–383 (1969)Google Scholar
  6. Grenier, J. F., Sava, G., Gillet, M.: Les résections étendues de l'intestin grêle. Étude physio-pathologique. Ann. Chir.24, 537–544 (1970)Google Scholar
  7. Hollender, L. F., Sava, G.: Étude clinique des résections étendues de l'intestin grêle. Ann. Chir.24, 529–534 (1970)Google Scholar
  8. Munck, B. G.: Galactose inhibition of transepithelial net transport as a result of stimulation of bidirectional efflux from the epithelium. Biochim. biophys. Acta (Amst.)266, 639–648 (1972)Google Scholar
  9. Parsons, D. S., Paterson, C. R.: Fluid and solute transport across rat colonic mucosa. Quart. J. exp. Physiol.65, 220–231 (1965)Google Scholar
  10. Robinson, J. W. L.: Interactions between neutral and dibasic amino acids for uptake by the rat intestine. Europ. J. Biochem.7, 78–89 (1968)Google Scholar
  11. Robinson, J. W. L.: Comparative aspects of the response of the intestine to its ionic environment. Comp. Biochem. Physiol.34, 641–655 (1970)Google Scholar
  12. Robinson, J. W. L.: Experimental intestinal malabsorption states and their relation to clinical syndromes. Klin. Wschr.50, 173–185 (1972)Google Scholar
  13. Robinson, J. W. L., Haroud, M., Luisier, A.-L., Winistörfer, B., Mirkovitch, V.: Fonction et structure de la muqueuse intestinale à la suite d'une résection étendue du grêle. Med. et Hyg. (Genève)31, 1319 (1973)Google Scholar
  14. Robinson, J. W. L., Rausis, C., Basset, P., Mirkovitch, V.: Functional and morphological response of the dog colon to ischaemia. Gut13, 775–783 (1972)Google Scholar
  15. Robinson, J. W. L., Taminelli, F., Felber, J.-P., Magnenat, P.: In vitro measurement of amino-acid uptake by the human small intestine. Med. exp. (Basel)10, 157–163 (1964)Google Scholar
  16. Schlenker, J. D., Robinson, J. W. L.: Studies on the permeability barrier to aminoacid penetration of the intestinal mucosa during incubation in vitro in a Na+-free buffer. Pflügers Arch. ges. Physiol.294, 169–181 (1967)Google Scholar
  17. Schultz, S. G., Curran, P. F.: Coupled transport of sodium and organic solutes. Physiol. Rev.50, 637–718 (1970)Google Scholar
  18. Worbe, J. F., Mottaz, P., Richardot, D.: L'absorption du glucose par la paroi du caecum du rat. C. R. Soc. Biol. (Paris)165, 1066–1070 (1971)Google Scholar

Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • J. W. L. Robinson
    • 1
  • A. -L. Luisier
    • 1
  • V. Mirkovitch
    • 1
  1. 1.Départment de Chirurgie ExpérimentaleHôpital Cantonal UniversitaireLausanneSuisse

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