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Der Hering-Breuer-Reflex bei künstlicher Beatmung des Kaninchens

VI. Die Wirkung von intermittierender, durch den Respirator gesteuerter, eoektrischer Reizung der Medulla oblongata

The Hering-Breuer reflex during artificial respiration in the rabbit

VI. The effect of intermittent bulbar stimulation driven by the respirator

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Summary

  1. 1.

    Anesthetized, non-curarized rabbits were artificially ventilated at such high rate and small inflation volume that the inspirations no longer closely followed upon the deflation phases of the respirator.

  2. 2.

    In this condition the medulla oblongata was electrically stimulated. One volley of repetitive stimuli per cycle of the respirator (inflation and deflation) was applied, the volleys lasting 1/6th of one cycle's duration. When certain points were stimulated the inspirations closely followed upon the combined artificial ventilation and bulbar stimulation.

  3. 3.

    100 and 150 impulses per second proved to be optimal to elicit the inspirations, whereas 20 impulses per second were ineffective.

  4. 4.

    The influence of bulbar stimulation with 100 impulses per second upon the spontaneous respiration was examined, the parameters being the same as in combined artificial ventilation and stimulation. In and expiratory effects occurred. When certain points were stimulated the inspirations closely followed upon the stimulus volleys.

  5. 5.

    At some points inspirations could only be elicited by combined artificial ventilation and bulbar stimulation. At other points the threshold voltage was lower in combined ventilation and central stimulation than in stimulation alone. Results suggest that during certain phases artificial ventilation exerts an inspiration-facilitating influence upon the bulbar reticular formation.

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Authors and Affiliations

  1. Physiologisches Institut der Universität Basel, Basel, Schweiz

    Marc Fallert

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  1. Marc Fallert
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Die Untersuchungen wurden in verdankenswerter Weise unterstützt durch die Sandoz-Stiftung zur Förderung der medizinisch-biologischen Forschung und durch die Freiwillige Akademische Gesellschaft der Stadt Basel.

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Fallert, M. Der Hering-Breuer-Reflex bei künstlicher Beatmung des Kaninchens. Pflugers Arch. 343, 107–122 (1973). https://doi.org/10.1007/BF00585706

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  • DOI: https://doi.org/10.1007/BF00585706

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