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Virchows Archiv A

, Volume 398, Issue 1, pp 87–99 | Cite as

Morphometric lightmicroscopic and immunohistochemical analyses of differentiated thyroid carcinomas

  • H. Dralle
  • W. Böcker
  • G. Nielson
  • W. Rehpenning
Article

Summary

Twenty-four differentiated human thyroid carcinomas were investigated light microscopically and immunohistochemically by morphometric methods. The study revealed that thyroglobulin synthesis in follicular and papillary carcinomas is independent of tumor type and histostructural differentiation. The immunohistochemical results suggest that a defect in thyroglobulin synthesis and thyroglobulin secretion in addition to iodine accumulation and organification defects impairs the effectiveness of postoperative radioiodine treatment of differentiated thyroid carcinomas.

Key words

Thyroid cancer Thyroglobulin Immunohistochemistry Morphometry 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • H. Dralle
    • 1
  • W. Böcker
    • 2
  • G. Nielson
    • 2
  • W. Rehpenning
    • 3
  1. 1.Klinik für Abdominal- und Transplantationschirurgie der Medizinischen Hochschule HannoverHannover 61Bundesrepublik Deutschland
  2. 2.Institut für Pathologie der Universität HamburgHamburg 20Bundesrepublik Deutschland
  3. 3.Mathematisches Institut der Universität HamburgHamburgBundesrepublik Deutschland

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