Synovial sarcoma enzyme histochemistry of a typical case
A typical case of biphasic synovial sarcoma was studied using enzyme histochemistry. A marked difference between the staining characteristics of the spindle cells and the epithelial-like cells was demonstrated by reactions for various hydrolytic enzymes. The epithelial-like cells exhibited a strong reactivity for alkaline phosphatase, acid phosphatase, adenosine triphosphatase and nonspecific esterase, whereas spindle-cells were completely unreactive when tested for these enzymes.
This is, to our knowledge, the first report demonstrating differences in the enzymatic pattern of the two cell populations which compose synovial sarcoma.
Key wordsSynovial sarcoma Enzyme histochemistry
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- Buonassisi V, Ozzello L (1973) Sulfated mucopolysaccharide production by synovial sarcoma cells in vivo and in tissue culture. Cancer Res 33:874–881Google Scholar
- Chilosi M, Menestrina F, Pizzolo G, Maconi A, Iannucci A, Bonetti F, Fiore-Donati L (1981) Fluoride resistantα-naphthyl acetate esterase and combined enzyme histochemistry in the study of normal and pathologic lymphoid tissues. Basic Appl histochem 25:39–50Google Scholar
- Chilosi M, Pizzolo G, Menestrina F, Iannucci AM, Bonetti F, Fiore-Donati L (1981a) Enzyme Histochemistry on Normal and Pathologic Paraffin-embedded lymphoid Tissues. Am J Clin Pathol 76:729–736Google Scholar
- Cooney TP, Hwang WS, Robertson DI, Hoogstraten J (1982) Monophasic synovial sarcoma, epithelioid sarcoma and chordoid sarcoma: ultrastructural evidence for a common histogenesis, despite light microscopic diversity. Histopathology 6:163–190Google Scholar
- Fernandez BB, Hernandez FJ (1976) Poorly differentiated synovial sarcoma. A light and electron microscopic study. Arch Pathol Lab Med 100:221–223Google Scholar
- Gabbiani G, Kaye GI, Lattes R, Majno G (1971) Synovial sarcoma. Electron microscopic study of a typical case; Cancer 28:1031–1039Google Scholar
- Hajdu SI, Shin MH, Fortner JG (1977) Tendosynovial sarcoma. A clinico pathological study of 136 cases. Cancer 39:1201–1217Google Scholar
- Ichinose H, Powell L, Hoerner HE, Derbes VJ. Byers JF (1979) The potential histogenic relationship of the peripheral nerve to synovioma. Cancer Res 39:4270–4273Google Scholar
- Katenkamp D, Stiller D (1980) Synovial sarcoma of the abdominal wall. Light microscopic, histochemical and electron microscopic investigations. Virchows Arch [Pathol Anat] 388:349–360Google Scholar
- Mackenzie DH (1966) Synovial sarcoma. A review of 58 cases. Cancer 19:169–180Google Scholar
- Mickelson MR, Brown GA, Maynard JA, Cooper RR, Bonfiglio M (1980) Synovial sarcoma. An electron microscopic study of monophasic and biphasic forms. Cancer 45:2109–2118Google Scholar
- Roth JA, Enzinger FM, Tannenbaum M (1975) Synovial sarcoma of the neck: a follow-up study of 24 cases. Cancer 35:1243–1253Google Scholar
- Sloane JP, Ormerod MG (1981) Distribution of epithelial membrane antigen in normal and neoplastic tissues and its value in diagnostic tumor pathology. Cancer 47:1786–1795Google Scholar