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Effect of alpha adrenergic receptor stimulation on integrated systemic venous bed

Pflügers Archiv volume 370, pages 241–246 (1977)Cite this article

Summary

In 29 mongrel dogs, venous return was completely drained from the caval veins to an oxygenator and returned to the femoral arteries with a roller pump at a constant perfusion rate. Blood pressures in both caval veins were kept constant by an automatic control system. The oxygenator weight was recorded and showed changes of the intracorporeal blood volume, i. e. of systemic venous blood volume since allowance was made for parallel changes in arterial blood volume.

Xylometazolin (5–20 μg/kg) and norepinephrine (2–8 μg/kg), both infused within 3 min, decreased systemic venous blood volume by up to 7 ml/kg. After denervation of arterial pressoreceptors, nearly similar results were obtained. After beta receptor blockade with prindolol (600 μg/kg), the effects on venous system were unchanged. After alpha receptor blockade with phentolamin (2500 μg/kg), all effects were abolished. Phentolamin as such increased venous volume by 3 ml/kg.

It is concluded that stimulation of venous alpha receptors effects predominantly a constriction of the systemic venous bed and hereby must increase venous return and cardiac output.

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Authors and Affiliations

  1. Physiologisches Insitut I, Universität Düsseldorf, Moorenstraße 5, D-4000, Düsseldorf 1, Germany

    E. R. Müller-Ruchholtz, H. -M. Lösch, E. Grund & W. Lochner

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  1. E. R. Müller-Ruchholtz
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  2. H. -M. Lösch
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  3. E. Grund
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  4. W. Lochner
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Müller-Ruchholtz, E.R., Lösch, H.M., Grund, E. et al. Effect of alpha adrenergic receptor stimulation on integrated systemic venous bed. Pflugers Arch. 370, 241–246 (1977). https://doi.org/10.1007/BF00585533

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  • DOI: https://doi.org/10.1007/BF00585533

Key words

  • Alpha adrenergic receptors
  • Venous system
  • Xylometazolin
  • Norepinephrine
  • Phentolamin