Pflügers Archiv

, Volume 402, Issue 3, pp 312–316 | Cite as

Changes of ventilation and ventilatory response to hypoxia during the menstrual cycle

  • Nariko Takano
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology

Abstract

The relationship between change in hypoxic sensitivity in respiration, defined as increment in ventilation per drop of arterial O2 saturation\(\left( {\Delta \dot V_{\text{E}} /\Delta S_{a_{{\text{O}}_2 } } } \right)\), with the phase change from follicular to luteal and those in resting pulmonary ventilation\(\left( {\dot V_{\text{E}} } \right)\), mean inspiratory flow (VT/TI), alveolar partial pressures of CO2 and O2 (\(P_{A_{{\text{CO}}_{\text{2}} } }\) and\(P_{A_{{\text{O}}_{\text{2}} } }\), respectively) and body temperature was studied in 10 women. There was a significant relationship between % increase in hypoxic sensitivity and decrement of resting\(P_{A_{{\text{CO}}_{\text{2}} } }\) that occurred in the luteal phase. However, no significant relationships were observed between change in hypoxic sensitivity and those in the remaining parameters studied. The intersubject variation in % increase in resting\(\dot V_{\text{E}}\) during the luteal phase was not associated with that in % increase in hypoxic sensitivity. The results indicate that the contribution of increased hypoxic sensitivity to increasing\(\dot V_{\text{E}}\) during the luteal phase is variable among subjects. Reasons for the increase in hypoxic sensitivity with hypocapnia are discussed.

Key words

Progesterone-induced hyperventilation Ventilatory response to hypoxia Hypocapnia Menstrual cycle 

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Nariko Takano
    • 1
  1. 1.Physiology Laboratory, Department of School Health, Faculty of EducationKanazawa UniversityKanazawaJapan

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