Abstract
Summary
The quasistatic and dynamic elastic behaviour of the tail artery of male normotensive (NCR) and spontaneously hypertensive (SHR) rats was determined in vitro. The tone of the smooth muscle was enhanced by norepinephrine and diminished by papaverine. The circumferential wall stress was changed by varying the transmural pressure level. The experimental procedure was the same as that used in a previous investigation (Bauer and Pasch, 1971). The circumferential (tangential) elastic wall modulusE t was calculated from the mean internal and external radii determined at each pressure level and from dynamic pressure-volume recordings in the frequency range between 0.03 and 20 Hz. The calculation was based on a formula valid for thick-walled, longitudinally constrained vessels.
Results
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1.
The cross-sectional wall area is only slightly increased in SHR as compared with NCR. While under norepinephrine the quasistatic pressure-radius loops are virtually identical in NCR and SHR, the loops obtained under papaverine are shifted towards significantly greater radii in NCR than in SHR. It is concluded that in SHR there is a change in the structure of the non-muscular wall elements, but no essential alteration of the smooth muscle.
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2.
The dynamic elastic modulusE d (real part ofE t) increases with increasing wall stress σ t . In NCR, theE d − σ t regression line for papaverine is significantly shifted towards higher moduli as compared with that for norepinephrine. This shift is only small in SHR.
At a given wall stress,E d is virtually independent of frequency within the range investigated in both NCR and SHR.
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3.
The loss modulus ωηw (imaginary part ofE t) shows virtually the same dependence on the wall stress asE d. It increases markedly with frequency in NCR and SHR.
There is a clear difference between the effects of spontaneous hypertension on the tail artery and on the peripheral resistance vessels.
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References
Amer, M. S.: Cyclic adenosine monophosphate and hypertension in rats. Science179, 807–809 (1973)
Bader, H.: The anatomy and physiology of the vascular wall. In: Handbook of physiology. Sect. 2: Circulation, Vol. II, pp. 865–889. Washington: Amer. Physiol. Soc. 1963
Bauer, R. D., Pasch, Th.: The quasistatic and dynamic circumferential elastic modulus of the rat tail artery studied at various wall stresses and tones of the vascular smooth muscle. Pflügers Arch.330, 335–346 (1971)
Bergel, D. H.: The dynamic elastic properties of the arterial wall. J. Physiol. (Lond.)156, 458–469 (1961)
Bohr, D. F.: Reactivity of vascular smooth muscle from normal and hypertensive rats: Effect of several cations. Fed. Proc.33, 127–132 (1974)
Ferrari, M.: Effects of papaverine on smooth muscle and their mechanisms. Pharmacol. Res. Comm.6, 97–115 (1974)
Folkow, B., Hallbäck, M., Lundgren, Y., Weiss, L.: Background of increased flow resistance and vascular reactivity in spontancously hypertensive rats. Acta Physiol. scand.80, 93–106 (1970)
Frank, O.: Die Analyse endlicher Dehnungen und die Elastizität des Kautschuks. Ann. Physik21, 602–608 (1906)
Frank, O.: Elastizität der Blutgefäße. Z. Biol.71, 255–272 (1920)
Gow, B. S.: The influence of vascular smooth muscle on the viscoelastic properties of blood vessels. In: Cardiovascular fluid dynamics, Vol. 2 (D. H. Bergel, ed.) pp. 65–110. London New York. Academic Press 1972
Hallbäck, M., Lundgren, Y., Weiss, L.: Reactivity to noradrenaline of aortic strips and portal veins from spontaneously hypertensive and normotensive rats. Acta physiol. scand.81, 176–181 (1971)
Hallbäck, M., Lundgren, Y., Weiss, L.: The distensibility of the resistance vessels in spontaneously hypertensive rats (SHR) as compared with normotensive control rats (NCR). Acta physiol. scand.90, 57–68 (1974)
Hinke, J. A. M.: In vitro demonstration of vascular hyper-responsiveness in experimental hypertension. Circulat. Res.17, 359–371 (1965)
Hutchins, P. M., Greene, A. W., Rains, T. D.: Effect of Isoproterenol on the blood vessels of spontaneously hypertensive rats. Microvasc. Res.9, 101–106 (1975)
Körner, H., Bauer, R. D., Busse, R., Pasch, Th., Sperling, W.: Problems in indirect blood pressure measurement in the rat tail artery. Pflügers Arch.343, R32 (1973)
Ramanathan, S., Shibata, S.: Cyclic AMP blood vessels of spontaneously hypertensive rat. Blood Vessels11, 312–318 (1974)
Remington, J. W.: The physiology of the aorta and major arteries. In: Handbook of physiology, Sect. 2: Circulation, Vol. II, pp. 799–838. Washington: Amer. Physiol. Soc. 1963
Triner, L., Vulliernox, Y., Verosky, M., Habit, D. V., Nahas, G. G.: Adenyl cyclase-phosphodiesterase system in arterial smooth muscle. Life Sci.11 (part. I), 817–824 (1972)
Wetterer, E., Kenner, Th.: Grundlagen der Dynamik des Arterienpulses. Berlin-Heidelberg-New York: Springer 1968
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Busse, R., Bauer, R.D., Summa, Y. et al. Comparison of the visco-elastic properties of the tail artery in spontaneously hypertensive and normotensive rats. Pflugers Arch. 364, 175–181 (1976). https://doi.org/10.1007/BF00585187
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DOI: https://doi.org/10.1007/BF00585187