Summary
A definition of cortical and juxta-medullary regions is suggested based on a grouping of nephrons of common flow characteristics. A possible error is suggested in the xenon clearance method of measuring the regional flows. Experiments to test the source of error and its magnitude are described. It is concluded that while the error is present its effect on conventional component analysis is small.
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References
Kety, S. S.: The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol. Rev. 3, 1–38 (1951)
Ladefoged, J.: Measurements of the renal blood flow in man with the133xenon wash-out technique. Scand. J. clin. Lab. Invest.18, 299–315 (1966)
Nashat, F. S., Scholefield, F. R., Tappin, J. W., Wilcox, C. S.: The effects of changes in haematocrit on the intrarenal distribution of blood flow in the dog's kidney. J. Physiol (Lond.)201, 639–655 (1969)
Thorburn, G. D., Kopald, H. H., Herd, A., Hollenburg, M., O'Morchoe, C. C., Barger, A. C.: Intrarenal distribution of nutrient blood flow determined with krypton85 in the unanaesthetized dog. Circulat. Res.XIII, 290–307 (1963)
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Devonshire, R.E., Nashat, F.S. & Tappin, J.W. An examination of the xenon clearance method. Pflugers Arch. 364, 161–165 (1976). https://doi.org/10.1007/BF00585185
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DOI: https://doi.org/10.1007/BF00585185