Pflügers Archiv

, Volume 397, Issue 1, pp 54–56 | Cite as

Calmodulin-dependent Ca2+ transport in erythrocytes of spontaneously hypertensive rats

  • S. N. Orlov
  • N. I. Pokudin
  • Yu. V. Postnov
Heart, Circulation, Respiration and Blood; Environmental and Exercise Physiology


Ca2+ transport in inside-out vesicles of the erythrocyte membranes of spontaneously hypertensive rats (SHR) was studied. In the presence of calmodulin, the rate of45Ca uptake by the erythrocyte membranes of SHR was half that of erythrocyte membranes of the normotensive control group. It is suggested that the decrease of the rate of calmodulin-dependent calcium transport across the plasma membrane may be a cause for the increased intracellular calcium content found in some tissues of spontaneously hypertensive rats in previous studies.

Key words

Spontaneous hypertension Erythrocytes Calcium pump Calmodulin 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • S. N. Orlov
    • 1
  • N. I. Pokudin
    • 1
  • Yu. V. Postnov
    • 1
  1. 1.Central Research Laboratory of the Ministry of Public Health of the USSRMoscowUSSR

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