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  • Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands
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Glomerular filtration in the isolated perfused kidney

II. Glomerular hemodynamics

Pflügers Archiv volume 397, pages 48–53 (1983)Cite this article

Abstract

Glomerular hemodynamics were studied of isolated perfused kidneys of 12-wk-old normotensive (NR) and spontaneously hypertensive (SHR) rats, using Pluronic F108 (BASF, Wyandotte, MI, USA) as a plasma expander. Glomerular filtration rate (GFR), proximal tubular hydrostatic pressure (P T) and glomerular capillary hydrostatic pressure (P GC) were approximately linearly related with renal perfusion pressure.P GC measured directly by micropuncture was comparable toP GC calculated from other parameters of glomerular dynamics using pore theory.

We conclude that GFR in isolated kidneys perfused with Pluronic F108 is lower than in vivo, mainly as a result of an increase inP T. This rise in tubular pressure is due to an increased urine flow rate and an elevated tubular fluid viscosity. The difference in glomerular dynamics between NR and SHR kidneys is the result of an increased preglomerular vascular resistance in SHR, possibly due to an adaptive hypertrophic reaction to a sustained hypertension.

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Affiliations

  1. Department of Physiology, University of Nijmegen, P. O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands

    H. M. Brink, W. M. Moons & J. F. G. Slegers

Authors
  1. H. M. Brink
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  2. W. M. Moons
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  3. J. F. G. Slegers
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Brink, H.M., Moons, W.M. & Slegers, J.F.G. Glomerular filtration in the isolated perfused kidney. Pflugers Arch. 397, 48–53 (1983). https://doi.org/10.1007/BF00585167

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Key words

  • Pluronic F108
  • Vascular resistance
  • Hypertension