Archiv für dermatologische Forschung

, Volume 240, Issue 3, pp 301–306 | Cite as

Hemmung der bildung von melanoidem pigment durch penicillamin bei trichophyton-arten

  • B. -R. Balda
  • W. Meinhof
Article
  • 19 Downloads

Zusammenfassung

  1. 1.

    Penicillamin hemmt die Bildung melanoiden Pigments bei Trichophyton rubrum var. nigricans und Trichophyton mentagrophytes var. goetzii, ohne das Wachstum der Pilze zu beeinflussen.

     
  2. 2.

    Kupferchlorid kann den Penicillamin-Effekt aufheben.

     
  3. 3.

    Die Wirkung von Penicillamin beruht wahrscheinlich auf einer Chelierung des Enzymkupfers der Tyrosinase.

     
  4. 4.

    Es wird diskutiert, ob diese Befunde auch für andere Organismen von Bedeutung sein können.

     

Inhibition of melanoid pigment production in two trichophyton species by penicillamine

Summary

  1. 1.

    Penicillamine inhibits the production of melanoid pigment in Trichophyton rubrum var. nigricans and Trichophyton mentagrophytes var. goetzii but has no influence on the growth of these fungi.

     
  2. 2.

    It is possible to reverse the effect of penicillamine by addition of CuCl2.

     
  3. 3.

    The inhibitory effect of penicillamine is probably based on chelation of the enzyme-copper of tyrosinase.

     
  4. 4.

    It is supposed that these findings may be of interest for studies in other organisms.

     

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Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • B. -R. Balda
    • 1
  • W. Meinhof
    • 1
  1. 1.Dermatologische Klinik und PoliklinikLudwig Maximilians-Universität MünchenGermany

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