Abstract
We have investigated the effect of isoprenaline on the amplitude of the transient contraction of isolated arteries induced by releasing the intracellular Ca with an agonist during incubation in a Ca-free solution. Under some conditions this force development is an indication of the amount of Ca in the intracellular store. Loading the store in high K+ solution in the presence of isoprenaline increases the amplitude of the subsequent contraction in Ca-free solution by 6 to 16% as compared to the control. The presence of isoprenaline during the loading procedure in the control solution with 5.9 mM K+ does not affect the amplitude of the subsequent contraction of the rabbit ear artery. In the rabbit coronary artery such pretreatment with isoprenaline inhibits the contraction to 40% of the control. These results indicate that β-agonists may stimulate the Ca uptake in the intracellular store and, depending on the tissue, inhibit the influx of Ca.
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Van Eldere, J., Raeymaekers, L. & Casteels, R. Effect of isoprenaline on intracellular Ca uptake and on Ca influx in arterial smooth muscle. Pflugers Arch. 395, 81–83 (1982). https://doi.org/10.1007/BF00584974
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DOI: https://doi.org/10.1007/BF00584974