Pflügers Archiv

, Volume 376, Issue 3, pp 193–199 | Cite as

Bicarbonate reabsorption in chronic renal failure studies in man and the rat

  • Jose A. L. Arruda
  • Luiz Nascimento
  • Gilberto Arevalo
  • Robert L. Baranowski
  • Andrew Cubria
  • Thomas Carrasquillo
  • Christof Westenfelder
  • Neil A. Kurtzman
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands

Abstract

Bicarbonate reabsorption during bicarbonate loading was measured in rats and in patients with chronic renal failure (CRF) and in normal human subjects. Bicarbonate reabsorption expressed as Tm/GFR was not significantly different between normal and CRF rats despite the fact that fractional chloride excretion was significantly greater (an indication of volume expansion) in CRF rats than in normals. The ratio of absolute bicarbonate reabsorption/absolute sodium reabsorption, a parameter which corrects for the influence of volume on bicarbonate reabsorption, was significantly higher in CRF rats than in normals. In patients with CRF, bicarbonate reabsorption expressed either as Tm/GFR or as the ratio of absolute bicarbonate reabsorption/absolute sodium reabsorption was not different from that of the normal subjects. In patients with CRF, glomerular filtration rate (GFR) varied between 3 and 47 ml/min. The ratio of absolute bicarbonate reabsorption/absolute sodium reabsorption was inversely and significantly related to GFR, i.e. as nephron mass decreases sodium bicarbonate is preferentially reabsorbed over sodium chloride. These data demonstrate that in CRF bicarbonate reabsorption is enhanced relative to that of sodium and chloride in man.

Key words

H+ secretion Decreased GFR Acid-base physiology Chronic renal failure Bicarbonate reabsorption 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Jose A. L. Arruda
    • 1
    • 2
  • Luiz Nascimento
    • 1
    • 2
  • Gilberto Arevalo
    • 1
    • 2
  • Robert L. Baranowski
    • 1
    • 2
  • Andrew Cubria
    • 1
    • 2
  • Thomas Carrasquillo
    • 1
    • 2
  • Christof Westenfelder
    • 1
    • 2
  • Neil A. Kurtzman
    • 1
    • 2
  1. 1.Section of NephrologyUniversity of Illinois, Abraham Lincoln School of MedicineChicagoUSA
  2. 2.Veterans Administration West Side HospitalChicagoUSA

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