Pflügers Archiv

, Volume 373, Issue 2, pp 161–165 | Cite as

Influence of renal nerves on renin secretion in the conscious dog

  • Bruno Grandjean
  • Guy Annat
  • Madeleine Vincent
  • Jean Sassard
Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands


In order to evaluate the influence of renal nerves on renin secretion during changes in blood volume, we studied the mean arterial blood pressure (MAP) and the renal venous plasma renin activity (PRA) in 6 conscious dogs having one intact and one denervated kidney.

After a passive head-up tilt PRA increased significantly in the vein of the intact kidney while it remained stable in the denervated one.

The intravenous injection of Furosemide (3 mg/kg) induced a rapid elevation of PRA in both renal veins. The kinetics of the variations of renin secretion were similar in the two kidneys, but its magnitude was significantly lower in the denervated side.

After a slow hemorrhage of 2, 4 and 6 ml/kg, MAP was unchanged and PRA increased in both renal veins but in a significantly lower degree in the denervated side. When blood loss reached 8 ml/kg, MAP decreased and PRA increased identically in the two renal veins.

It was concluded that, in conscious dogs, the renal nerves could participate in the rapid adaptations of renin secretion during small changes in the circulating blood volume.

Key words

Renin secretion Blood volume Renal nerves Conscious dogs 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Annat, G., Grandjean, B., Vincent, M., Jarsaillon, E., Sassard, J.: Effects of right atrial stretch on plasma renin activity. Arch. Int. Physiol. Biochem.84, 311–315 (1976)Google Scholar
  2. Bencsath, P., Szalay, L., Debreczeni, L. A., Vajda, L., Takacs L., Fischer, A.: Denervation diuresis and renin secretion in the anaesthetized dog. Europ. J. Clin. Invest.2, 422–425 (1972)Google Scholar
  3. Bertoncello, I., Naughton, R. J., Skinner, S. L.: Sensitivity of renin secretion to volume depletion in the anaesthetized dog: comparison between urinary drainage and slow hemorrage. J. Physiol. (Lond.)259, 309–324 (1976)Google Scholar
  4. Bozovic, L., Castenfors, J., Oro, L.: Plasma renin activity in patients with disturbed sympathetic vasomotor control (postural hypotension). Acta Med. Scand.188, 385–388 (1970)Google Scholar
  5. Brennan, L. A., Jr., Malvin, R. L., Jochim, K. E., Roberts, D. E.: Influence of right and left atrial receptors on plasma concentrations of A.D.H. and renin. Am. J. Physiol.221, 273–278 (1971)Google Scholar
  6. Brubacher, E. S., Vander, A. J.: Sodium deprivation and renin secretion in unanesthetized dogs. Am. J. Physiol.214, 15–21 (1968)Google Scholar
  7. Bunag, R. D., Page, I. H., Mc Cubbin, J. W.: Neural stimulation of release of renin. Circ. Res.19, 851–858 (1966)Google Scholar
  8. Coote, J. H., Johns, E. J., Mc Leod, V. H., Singer, B.: Effect of renal nerve stimulation, renal blood flow and adrenergic blockade on plasma renin activity in the cat. J. Physiol. (Lond.)226, 15–3 (1972)Google Scholar
  9. Corsini, W. A., Hook, J. B., Bailie, M. D.: Control of renin secretion in the dog. Effects of Furosemide on the vascular and macula-densa receptors. Circ. Res.37, 464–470 (1975)Google Scholar
  10. Davis, J. O., Freeman, R. H.: Mechanisms regulating renin release. Physiol. Rev.56, 1–56 (1976)Google Scholar
  11. Hackl, J. M., Skrabal, F.: Plasma renin activity, plasma aldosterone and electrolytes balance in post operative period. Anesthesist24, 477–482 (1975)Google Scholar
  12. Hodge, R. L., Lowe, R. D., Vane, J. R.: The effects of alteration of blood volume on the concentration of circulating angiotensin in anaesthetized dogs. J. Physiol. (Lond.)185, 613–626 (1966)Google Scholar
  13. Johnson, J. A., Davis, J. O., Witty, R. T.: Effects of catecholamines and renal nerves stimulation on renin release in the non-filtering kidney. Circ. Res.29, 646–653 (1971)Google Scholar
  14. Lagrange, R. G., Sloop, C. H., Schmid, J. S.: Selective stimulation of renal nerves in the anaesthetized dog: effects on renin release during controlled changes in renal hemodynamics. Circ. Res.33, 704–712 (1973)Google Scholar
  15. Ludens, J. H., Williamson, H. E.: Effects of Furosemide on renal blood flow in the conscious dog. Proc. Soc. Exp. Biol. Med.133, 513–515 (1970)Google Scholar
  16. Mogil, R. A., Itskovitz, H. D., Russel, J. H., Murphy, J. J.: Renal innervation and renin activity in salt metabolism and hypertension. Am. J. Physiol.216, 693–697 (1969)Google Scholar
  17. Molzahn, M., Dissmann, T. A., Haltin, S., Lohmann, F. W., Oelkers, W.: Orthostatic changes of hemodynamics, renal function, plasma catecholamines and plasma renin concentration in normal and hypertensive man. Clin. Sci.42, 209–222 (1972)Google Scholar
  18. Naughton, R. J., Bertoncello, I., Skinner, S. L.: Abolition of the renin releasing action of Furosemide by acute renal denervation in dogs. Clin. Exp. Pharmacol. Physiol.2, 213–227 (1975)Google Scholar
  19. Pannier, C., Seroussi, J., Martinaud, J. P., Wassilikos, C., Durand, J.: Les volumes sanguins circulants chez l'Homme. Rev. Fr. Et. Clin. Biol.13, 124–128 (1968)Google Scholar
  20. Richardson, D., Stella, A., Leonetti, G., Bartorelli, A., Zanchetti, A.: Mechanisms of renal release of renin by electrical stimulation of the brain stem in the cat. Circ. Res.34, 425–434 (1974)Google Scholar
  21. Robertson, D., Michelakis, A. M.: Effect of anesthesia and surgery on plasma renin activity in man. J. Clin. Endocrinol. Metab.34, 831–836 (1972)Google Scholar
  22. Sassard, J., Vincent, M., Annat, G., Bizollon, C. A.: A kinetic study of plasma renin and aldosterone during changes of posture in man. J. Clin. Endocrinol. Metab.42, 20–27 (1976)Google Scholar
  23. Schad, H., Seller, H.: Reduction of renal neve activity by volume expansion in conscious cats. Pflügers Arch.363, 155–159 (1976)Google Scholar
  24. Tanigawa, H., Dua, S. L., Assaykeen, T. A.: Effect of renal and adrenal denervation on the renin response to slow hemorrhage in dogs. Clin. Exp. Pharmacol. Physiol.1, 325–332 (1974)Google Scholar
  25. Vincent, M., Sassard, J., Cier, J. F.: Méthode rapide de détermination radioimmunologique de l'activité rénine du plasma. Rev. Eur. Et. Clin. Biol.17, 1001–1007 (1973)Google Scholar
  26. Witty, R. J., Davis, J. O., Johnson, J. A., Prewitt, R. L.: Effects of papaverine and hemorrhage on renin secretion in the nonfiltering kidney. Am. J. Physiol.221, 1661–1671 (1971)Google Scholar
  27. Zanchetti, A., Stella, A., Leonetti, G., Morganti, A., Terzoli, L.: Control of renin release: a review of experimental evidence and clinical implications. Am. J. Cardiol.37, 657–691 (1976)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Bruno Grandjean
    • 1
  • Guy Annat
    • 1
  • Madeleine Vincent
    • 1
  • Jean Sassard
    • 1
  1. 1.Laboratoire de Physiologie A, Faculté de Médecine et de PharmacieUniversité Lyon ILyonFrance

Personalised recommendations