Pflügers Archiv

, Volume 357, Issue 1–2, pp 35–49 | Cite as

Properties of mechanosensitive neurons within Auerbach's plexus of the small intestine of the cat

  • C. J. Mayer
  • J. D. Wood
Article

Summary

Three different kinds of mechanosensitive neurons were detected by direct electrical recording from Auerbach's plexus. Neurons classified as fast-adapting mechanoreceptors discharged spikes at the onset of stimulation, and the discharge stopped during a sustained stimulus of constant intensity. Slowly-adapting mechanoreceptors maintained during sustained stimulation, a steady discharge at a frequency that was a direct function of the intensity of the stimulus. Tonic-type neurons responded to mechanical stimulation with a prolonged train of spikes which had a consistent pattern from preparation to preparation. Once the tonic-type cells were triggered, the discharge followed a characteristic time course that was unchanged by further increase or decrease in stimulus intensity. Tonic-type neurons are probably not first order sensory neurons, but they may be activated by input derived from primary mechanoreceptors. Frequency of discharge of slowly-adapting mechanoreceptors was increased by histamine. This appeared to be secondary to histamine-induced contractile activity of the musculature.

Key words

Neurophysiology Enteric Nervous System Mechanoreceptors Gastrointestinal Function 

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References

  1. 1.
    Bessou, B., Perl, E. R.: A movement detector of the small intestine. J. Physiol. (Lond.)182, 404–426 (1966)Google Scholar
  2. 2.
    Davison, J. S.: Response of single vagal afferent fibres to mechanical and chemical stimulation of the gastric and duodenal mucosa in cats. Quart. J. exp. Physiol.57, 405–416 (1972)Google Scholar
  3. 3.
    Dowben, R. M., Rose, J. E.: A metal filled microelectrode. Science118, 22–24 (1953)Google Scholar
  4. 4.
    Gabella, G.: Fine structure of the myenteric plexus in the guinea-pig ileum. J. Anat. (Lond.)111, 69–97 (1972)Google Scholar
  5. 5.
    Gernand, T. B., Zotterman, Y.: Intestinal pain: an electrophysiological investigation on mesenteric nerves. Acta physiol. scand.12, 56–72 (1946)Google Scholar
  6. 6.
    Getchell, T. V.: Analysis of unitary spikes recorded extracellularly from frog olfactory receptor cells and axons. J. Physiol. (Lond.)234, 533–551 (1973)Google Scholar
  7. 7.
    Harding, R., Leek, B. F.: Gastro-duodenal receptor responses to chemical and mechanical stimuli, investigated by a “single fibre” technique. J. Physiol. (Lond.)222, 139–140 P (1972)Google Scholar
  8. 8.
    Iggo, A.: Gastrointestinal tension receptors with unmyelinated afferent fibers in the vagus of the cat. Quart. J. exp. Physiol.42, 130–141 (1957)Google Scholar
  9. 9.
    Mei, N.: Mecanorecepteurs Vagaux Digestifs chez le chat. Ex. Brain Res.11, 502–514 (1970)Google Scholar
  10. 10.
    Ohkawa, H., Prosser, C. L.: Electrical activity in myenteric and submucous plexuses of cat intestine. Amer. J. Physiol.222, 1412–1419 (1972)Google Scholar
  11. 11.
    Paintal, A. S.: A study of gastric stretch receptors. Their role in the peripheral mechanism of satiation of hunger and thirst. J. Physiol. (Lond.)126, 255–270 (1954)Google Scholar
  12. 12.
    Ranieri, F., Mei, N., Crousillat, J.: Les Afferences Splanchniques Provenant des Mecanorecepteurs Gastrointestinaux et Peritoneaux. Exp. Brain Res.16, 276–290 (1973)Google Scholar
  13. 13.
    Sharma, K. N., Jacobs, H. L., Gopal, V., Dua-Sharma, S.: Vagosympathetic modulation of gastric mechanoreceptors. Effects of distention and nutritional state. J. Neural Trans.33, 113–154 (1972)Google Scholar
  14. 14.
    Tamai, T., Prosser, C. L.: Differentiation of slow potentials and spikes in longitudinal muscle of cat intestine. Amer. J. Physiol.210, 412–458 (1966)Google Scholar
  15. 15.
    Wood, J. D.: Electrical activity from single neurons in Auerbach's plexus. Amer. J. Physiol.219, 159–169 (1970)Google Scholar
  16. 16.
    Wood, J. D.: Electrical discharge of single enteric neurons of guinea pig small intestine. Amer. J. Physiol.225, 1107–1113 (1973)Google Scholar
  17. 17.
    Wood, J. D. and Mayer, C. J.: Discharge patterns of single enteric neurons of the small intestine of the cat, dog and guinea pig. Proc. IV Inter. Symp. Gastrointestinal Motility. pp. 387–408. Vancouver, Brit. Col.: Mitchell Press 1974Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • C. J. Mayer
    • 1
  • J. D. Wood
    • 1
  1. 1.Department of PhysiologyUniversity of Kansas Medical CenterKansas CityUSA

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