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Pflügers Archiv

, Volume 405, Issue 2, pp 170–172 | Cite as

The effect of acute saline volume expansion on renal Na−K-ATPase

  • Michael M. Friedlaender
  • Hanna Wald
  • Mordechai M. Popovtzer
Excitable Tissues and Central Nervous Physiology Short Communication

Abstract

To examine the role of Na-K-ATPase in the natriuresis that occurs after acute extracellular volume expansion, we performed acute clearance experiments and in vitro analysis of renal microsomal ATPase activity in rats receiving intravenous 0.9% sodium chloride (0.1 ml/100g bw/min). Despite increased absolute reabsorption of filtered sodium (196±8.1 vs. 165±11.4 uEq/min, p<0.05), renal medullary microsomal Na-K-ATPase activity was decreased from 134±5.9 to 110±6.3 pmol Pi/mg protein/hour (p<0.02). No changes occurred in cortical or papillary regions and Mg-ATPase was unaffected. Similar results were obtained after adding 4 mEq/l potassium chloride to the infusion to prevent any fall in serum K+. These data suggest that a considerable percentage of sodium reabsorption is suppressed in acutely volume expanded animals and it is proposed that this is mediated by inhibition of medullary Na-K-ATPase.

Keywords

Sodium Chloride Potassium Sodium Chloride Human Physiology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Michael M. Friedlaender
    • 1
  • Hanna Wald
    • 1
  • Mordechai M. Popovtzer
    • 1
  1. 1.Nephrology ServicesHadassah University HospitalJerusalemIsrael

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