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Pflügers Archiv

, Volume 360, Issue 1, pp 81–89 | Cite as

Effects of certain diuretics on the electrophysiological characteristics of the nephron in the rat kidney

  • V. A. Kantariya
  • A. A. Lebedev
Article
  • 27 Downloads

Summary

Electrophysiological micropuncture techniques were used to study the effect of certain diuretics on transtubular transport of electrolytes in the rat kidney. The mercurial diuretic novurite caused a reduction of active sodium transport in the proximal tubule, measured by short-circuit current and increased permeability of the tubular wall to ions which led to a considerable drop in transtubular potential and transepithelial resistance. Ethacrynic acid decreased the shortcircuit current in the proximal tubule, without changing the permeability characteristics of the nephron. Xanthine diuretic euphylline did not reduced the short-circuit current in the proximal segment of the nephron; however, it increased the transepithelial potential of the renal tubule. In the distal tubule, euphylline and ethacrynic acid increased the difference in transtubular potential, whereas novurite distal tubule as a result of euphylline and ethacrynic acid action may be responsible for increasing potassium excretion. A decrease of the transtubular potential in the distal tubule under the action of novurite may serve to explain a lack of significant potassium excretion under mercurial diuretic action. The reduction of tubular reabsorption as a result of diuretic action is due to drug effect on different levels of the transtubular-ion transport system.

Key words

Micropuncture Active Transport Sodium Transport Potassium Transport Diuretics 

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • V. A. Kantariya
    • 1
  • A. A. Lebedev
    • 1
  1. 1.Chair of PharmacologyThe Ulyanov Memorial Kuibyshev Medical InstituteKuibyshevUSSR

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