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Pflügers Archiv

, Volume 360, Issue 1, pp 7–15 | Cite as

Oxygen supply and uptake in the liver and the intestine

  • J. Lutz
  • H. Henrich
  • E. Bauereisen
Article

Summary

The oxygen supply to the liver was found to be dependent on the total blood flow only and not on the ratio of arterial to portal contribution. The mean value of O2-uptake in the liver, related to a blood flow of 110 ml/min·100 g liver, amounted to 6.08±0.2 ml O2/min·100g liver (mean±S.E.M.). O2-uptake of the intestine was found to be 1.95±0.13 ml O2/min·100g tissue, related to a normal blood flow of 50 ml/min·100g tissue.

With low oxygen supply O2-extraction in the liver reaches values of 97%, whereas the intestinal extraction does not surpass 75%. A rise in oxygen supply surmounting normal values does not increase the O2-consumption.

Contrary to the intestinal circulation the liver showed no postocclusive vasodilatation. The oxygen debt was payed back by a greater extraction. The portal oxygen supply to the liver can markedly increase due to intestinal metabolic hyperemia.

High O2-extraction capacity, rather than vasodilatation, is the main mechanism for matching hepatic oxygen supply with requirements. The hepatic venous blood may leave the liver with an extremely low O2-content.

Key words

Hepatic Circulation Intestinal Circulation Hepatic Oxygen Uptake Hepatic Oxygen Supply 

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References

  1. Bartels, H., Harms, H.: Sauerstoffdissoziationskurven des Blutes von Säugetieren. Pflügers Arch. ges. Physiol268, 334–365 (1959)Google Scholar
  2. Bauereisen, E., Lutz, J., Ohnhaus, E., Peiper, U.: Druck-Stromstärke-Beziehungen in der Porta-Lebervenen-Strombahn. Pflügers Arch. ges. Physiol.289, 246–254 (1966)Google Scholar
  3. Blalock, A., Mason, M. F.: Observations on the blood flow and gaseous metabolism of the liver of unanesthetized dogs. Amer. J. Physiol.117, 328–334 (1936)Google Scholar
  4. Green, H. D., Hall, L. S., Sexton, J., Deal, D. P.: Autonomic vasomotor responses in the canine hepatic arterial and venous bed. Amer. J. Physiol.196, 196–202 (1959)Google Scholar
  5. Greenway, C. V., Stark, R. D.: Hepatic vascular bed. Physiol. Rev.51, 23–65 (1971)Google Scholar
  6. Hanson, K. M., Johnson, P. C.: Local control of hepatic arterial and portal venous flow in the dog. Amer. J. Physiol.211, 712–720 (1966)Google Scholar
  7. Kessler, M., Lang, H., Sinagowitz, E., Rink, R., Höper, J.: Homeostasis of oxygen supply in liver and kidney. In: Oxygen transport to tissue. Ed.: H. I. Bicher and D. F. Druley, pp. 351–369. New York: Plenum Press 1973Google Scholar
  8. Kramer, K., Driessen, G., Brechtelsbauer, H.: Lactate elimination and O2 consumption of the liver in narcotized dogs. Pflügers Arch.330, 195–205 (1971)Google Scholar
  9. Krarup, N., Larsen, J. A.: The effect of glucagon on hepatosplanchnic hemodynamics, functional capacity, and metabolism of the liver in cats. Acta physiol. scand.91, 42–52 (1974a)Google Scholar
  10. Krarup, N., Larsen, J. A.: The immediate effects of ligation of the hepatic artery on liver hemodynamics and liver function in the cat. Acta physiol. scand.91, 441–446 (1974b)Google Scholar
  11. Lübbers, D. W., Windisch, E.: Die Messung hoher Sauerstoffdrucke in kleinen Gasoder Flüssigkeitsmengen mit der Pt-Elektrode. Pflügers Arch. ges. Physiol.276, 429–434 (1962)Google Scholar
  12. Lundgren, O.: Studies on blood flow distribution and countercurrent exchange in the small intestine. Acta physiol. scand., Suppl.303, 1–42 (1967)Google Scholar
  13. Lutz, J.: Druckkonstante Perfusion von Teilkreisläufen mittels einer druckgesteuerten Rollenpumpe mit analoger Durchströmungsregistrierung. Pflügers Arch.335, R 89 (1972)Google Scholar
  14. Lutz, J., Bauereisen, E.: Abdominalorgane. In: E. Schütz und E. Bauereisen (Edit.) Physiologie des Kreislaufs, S. 229–292. Berlin-Heidelberg-New York: Springer 1971.Google Scholar
  15. Lutz, J., Peiper, U., Bauereisen, E.: Auftreten und Verhalten veno-vasomotischer Reaktionen in der Leberstrombahn. Pflügers Arch. ges. Physiol.299, 311–325 (1968)Google Scholar
  16. Peiper, U., Lutz, J., Wullstein, H. K.: Über die gegenseitige Beeinflussung der Durchblutung im Bereich von V. portae und A. hepatica. Z. Kreisl.-Forsch.58, 197–209 (1969)Google Scholar
  17. Scholtholt, J.: Das Verhalten der Durchblutung der Leber bei Steigerung des Sauerstoffverbrauches der Leber. Pflügers Arch.318, 202–216 (1970)Google Scholar
  18. Scholtholt, J., Shiraishi, T.: Die Wirkung einer allgemeinen Hypoxie, Hypocapnie und Hypercapnie auf die Durchblutung der Leber und des Splanchnicusgebietes des narkotisierten Hundes. Pflügers Arch.318, 185–201 (1970)Google Scholar
  19. Selkurt, E. E., Brecher, G. A.: Splanchnic hemodynamics and oxygen utilization during hemorrhagic shock in the dog. Circulat. Res.4, 693–704 (1956)Google Scholar
  20. Torrance, H. B.: The control of the hepatic arterial circulation. J. Physiol. (Lond.)158, 39–49 (1969)Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • J. Lutz
    • 1
  • H. Henrich
    • 1
  • E. Bauereisen
    • 1
  1. 1.Physiologisches Institut der Universität WürzburgGermany

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